IFPA Award in Placentology Lecture: Biology of the placental syncytiotrophoblast - Myths and facts
IFPA Award in Placentology Lecture: Biology of the placental syncytiotrophoblast - Myths and facts
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DOI：
10.1016/j.placenta.2009.12.001
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发表时间：
2010-03-01
期刊：
影响因子：
3.8
通讯作者：
Huppertz, B.
中科院分区：
文献类型：
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作者：
Huppertz, B.
大约15年前，细胞凋亡被认为在人类胎盘的发育中起作用。从那时起，越来越多的出版物表明，程序性细胞死亡在胎盘的生长和分化中起着至关重要的作用，特别是在绒毛滋养层中。在过去的十年中，建立了一个概念，将细胞凋亡的进展与细胞滋养细胞和合体滋养细胞的分化联系起来。因此，发育和维护的合胞体滋养层细胞依赖于精确的编排不同的过程和阶段的凋亡cascades.This审查的重点是维护和生长的合胞体滋养层细胞以及驱逐出境滋养层材料进入母体循环。核形态与转录活性有关，讨论了RNA的保护和储存策略，并强调了RNA和蛋白质的合胞体表达率之间的差异。此外，驱逐滋养层片段相关的形态结构（合胞体结）和它们对母体系统的影响。最后，不同的模式释放的滋养层细胞片段，如凋亡，aponecrotic和坏死的讨论是负责在先兆子痫的母体炎症反应。(C)2010年由IFPA和Elsevier Ltd.出版
About 15 years ago apoptosis was attributed a role in the development of the human placenta. Since then an increasing number of publications has shown that programmed cell death plays an essential role in placental growth and differentiation, especially in the villous trophoblast. During the last ten years a concept was established linking the progress of apoptosis to differentiation of cytotrophoblasts and syncytiotrophoblast. Thus, development and maintenance of the syncytiotrophoblast depends on the precise orchestration of different processes and stages of the apoptosis cascade.This review focuses on the maintenance and growth of the syncytiotrophoblast as well as the deportation of trophoblast material into the maternal circulation. Nuclear morphology is related to transcriptional activity, RNA protection and storage strategies are discussed and the differences between syncytial expression rates of RNA and protein are highlighted. Moreover, deportation of trophoblast fragments is related to the relevant morphological structures (syncytial knots) and to their effects on the maternal system. Finally, different modes of release of trophoblast fragments such as apoptotic, aponecrotic and necrotic are discussed as being responsible for the maternal inflammatory response during pre-eclampsia. (C) 2010 Published by IFPA and Elsevier Ltd.