NONPARATHYROID HUMORAL HYPERCALCEMIA IN PATIENTS WITH NEOPLASTIC DISEASES
NONPARATHYROID HUMORAL HYPERCALCEMIA IN PATIENTS WITH NEOPLASTIC DISEASES
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DOI：
10.1056/nejm197307262890403
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发表时间：
1973-01-01
影响因子：
158.5
通讯作者：
POTTS, JT
中科院分区：
文献类型：
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作者：
POWELL, D;SINGER, FR;POTTS, JT
11 名患者患有与各种非甲状旁腺肿瘤相关的高钙血症和低磷血症，但没有骨转移（假性甲状旁腺功能亢进症）。在九名患者中，手术消融或其他抗肿瘤治疗导致生化异常得到缓解。当采用多种免疫测定进行评估时，所有患者的外周血和肿瘤组织中都检测不到甲状旁腺激素，这些免疫测定不仅检测完整的甲状旁腺激素，还检测甲状旁腺原激素以及生物活性和非活性甲状旁腺激素片段。然而，组织提取物在体外引起骨中钙的主动吸收。假定的体液物质（或多种物质）的化学性质未知。研究结果表明，在许多具有假性甲状旁腺功能亢进症典型临床和生化特征的肿瘤患者中，甲状旁腺激素以外的某些体液物质必定是导致高钙血症和其疾病的其他特征的原因。 (新英格兰医学杂志 289:176–181, 1973)
Eleven patients had hypercalcemia and hypophosphatemia associated with various nonparathyroid neoplasms in the absence of bony metastases (pseudohyperparathyroidism). In nine patients surgical ablation or other antitumor therapy resulted in remission of the biochemical abnormalities. Parathyroid hormone was undetectable both in peripheral blood and in tumor tissue from all patients when assessed with multiple immunoassays that detect not only intact parathyroid hormone but proparathyroid hormone and biologically active and inactive parathyroid hormone fragments in addition. However, extracts of tissues caused active calcium resorption from bone in vitro. The chemical nature of the presumed humoral substance (or substances) is unknown. The findings suggest that in many patients with neoplasms and clinical and biochemical features typical of pseudohyperparathyroidism some humoral substance other than parathyroid hormone must be responsible for hypercalcemia and other features of their disease. (N Engl J Med 289:176–181, 1973)