A comparative study of healing of laser and scalpel incision wounds in rat oral mucosa.
A comparative study of healing of laser and scalpel incision wounds in rat oral mucosa.
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大鼠口腔粘膜激光和手术刀切口愈合的比较研究。
DOI：
10.1111/j.1600-0722.1987.tb01395.x
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
M. Luomanen
中科院分区：
文献类型：
--
作者：
M. Luomanen
对 22 只 Sprague-Dawley 大鼠舌粘膜激光和手术刀切口愈合过程中的毛细血管增殖和炎症细胞浸润进行了为期 28 天的评估。在舌中线两侧平行切开切口。术后立即、6小时、2、11和28天采集标本进行免疫组织化学和组织学检查。对免疫组织学染色的切片进行显微镜检查，检查因子 VIII 相关抗原（内皮细胞的标记物），结果表明，与手术刀切口相比，激光切口附近立即和早期愈合阶段的毛细血管数量较少。激光治疗部位愈合过程中毛细血管的增殖也受到阻碍。组织学标本的显微镜检查显示，与手术刀切口愈合相比，激光伤口愈合中炎症细胞浸润速度较慢，但更为突出。
Capillary proliferation and inflammatory cell infiltration were evaluated in healing laser and scalpel incision wounds in rat tongue mucosa in 22 Sprague-Dawley rats for a period of 28 days. The incisions were made in parallel on both sides of the midline of the tongue. Specimens for immunohistochemical and histologic examination were taken immediately, 6 h, 2, 11, and 28 days after the surgery. The microscopic inspection of the sections stained immunohistologically for factor VIII-related antigen, a marker for endothelial cells, suggested a smaller amount of capillaries immediately and during the early healing phase in the vicinity of the laser incisions when compared with the scalpel incisions. The proliferation of capillaries during healing was also retarded at the lasered sites. The microscopic inspection of the histologic specimens showed that the inflammatory cell infiltration appeared slower but was more prominent in the healing laser wounds than in the healing scalpel incision wounds.