Isolation, Structure Elucidation, and Iron-Binding Properties of Lystabactins, Siderophores Isolated from a Marine Pseudoalteromonas sp.
Isolation, Structure Elucidation, and Iron-Binding Properties of Lystabactins, Siderophores Isolated from a Marine Pseudoalteromonas sp.
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DOI：
10.1021/np3008655
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发表时间：
2013-04-01
影响因子：
5.1
通讯作者：
Butler, Alison
中科院分区：
文献类型：
--
作者：
Zane, Hannah K.;Butler, Alison
海洋细菌Pseudoalteromonas sp. S2 B，在深水地平线石油泄漏后从墨西哥湾分离出来，被发现产生lystabactins A，B和C（1-3），三种新的铁载体。通过质谱、氨基酸分析和NMR解析结构。Lystabactins由丝氨酸（Ser）、天冬酰胺（Asn）、两个甲酰化/羟基化的鸟氨酸（FOHOrn）、二羟基苯甲酸（Dhb）和一种非常不寻常的非蛋白质氨基酸4，8-二氨基-3-羟基辛酸（LySta）组成。通过分光光度竞争研究了化合物的铁结合性能。
The marine bacterium Pseudoalteromonas sp. S2B, isolated from the Gulf of Mexico after the Deepwater Horizon oil spill, was found to produce lystabactins A, B, and C (1-3), three new siderophores. The structures were elucidated through mass spectrometry, amino acid analysis, and NMR. The lystabactins are composed of serine (Ser), asparagine (Asn), two formylated/hydroxylated omithines (FOHOrn), dihydroxy benzoic acid (Dhb), and a very unusual nonproteinogenic amino acid, 4,8-diamino-3-hydroxyoctanoic acid (LySta). The iron-binding properties of the compounds were investigated through a spectrophotometric competition.