Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells
Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells
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DOI：
10.1073/pnas.0708469104
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发表时间：
2007-10-23
影响因子：
11.1
通讯作者：
Raz, Eyal
中科院分区：
文献类型：
--
作者：
Abe, Kazumichi;Nguyen, Kim Phung;Raz, Eyal
我们探讨了常规树突状细胞（cDC）在葡聚糖硫酸钠单周期给药诱导的急性结肠炎中的生理作用。根据其激活模式和独立于T细胞，cDC可以增强或减弱葡聚糖硫酸钠诱导的结肠炎的严重程度。后者的有益效果部分地通过Toll样受体9激活的cDC诱导的IFN-1实现。IFN-1通过调节中性粒细胞和单核细胞向发炎结肠的运输并抑制组织巨噬细胞的炎性产物来抑制结肠炎症。这些数据突出了cDC在调节其他先天免疫细胞中的新作用，并将其定位为急性结肠炎症的主要参与者。
We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis induced by a single cycle of dextran sodium sulfate administration. Depending on their mode of activation and independently of T cells, cDCs can enhance or attenuate the severity of dextran sodium sulfate-induced colitis. The latter beneficial effect was achieved, in part, by IFN-1 induced by Toll-like receptor 9-activated cDCs. IFN-1 inhibits colonic inflammation by regulating neutrophil and monocyte trafficking to the inflamed colon and restraining the inflammatory products of tissue macrophages. These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation.