Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects.
Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects.
复制标题
中枢血清素活性和攻击性：在人类受试者中，与催乳素对 d-芬氟拉明的反应呈负相关，但与 CSF 5-HIAA 浓度无关。
DOI：
10.1176/ajp.154.10.1430
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Hauger,RL
中科院分区：
文献类型：
--
作者：
Coccaro,EF;Kavoussi,RJ;Cooper,TB;Hauger,RL
ObjectiveThis study compared the nature and magnitude of the relationship between aggression and CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration with that between aggression and the prolactin response to d-fenfluramine challenge in human subjects.MethodThe Life History of Aggression assessment scores of 24 subjects with personality disorders were compared with their lumbar CSF 5-HIAA concentrations and with their prolactin responses to d-fenfluramine challenge.ResultsAggression was significantly and inversely correlated with prolactin responses to d-fenfluramine challenge but not with lumbar CSF 5-HIAA concentrations in these subjects.ConclusionsProlactin response to d-fenfluramine may be more sensitive than lumbar CSF 5-HIAA concentration in detecting a relationship between aggression and central serotonin activity in noncriminally violent human subjects.
