Association of the Mediterranean Dietary Pattern With the Incidence of Depression The Seguimiento Universidad de Navarra/University of Navarra Follow-up (SUN) Cohort
Association of the Mediterranean Dietary Pattern With the Incidence of Depression The Seguimiento Universidad de Navarra/University of Navarra Follow-up (SUN) Cohort
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DOI：
10.1001/archgenpsychiatry.2009.129
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发表时间：
2009-10-01
影响因子：
--
通讯作者：
Angel Martinez-Gonzalez, Miguel
中科院分区：
文献类型：
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作者：
Sanchez-Villegas, Almudena;Delgado-Rodriguez, Miguel;Angel Martinez-Gonzalez, Miguel
内容：坚持地中海饮食模式（MDP）被认为可以减少炎症，血管和代谢过程，可能参与临床depresson.Objective的风险：评估坚持MDP和临床depresson.Design的发病率之间的关联：前瞻性研究，使用验证的136项食物频率问卷，以评估坚持MDP。MDP得分对蔬菜、水果和坚果、谷物、豆类和鱼类的消费量、单不饱和脂肪酸与饱和脂肪酸的比例以及适度饮酒量进行了正加权，而对肉类或肉制品和全脂奶制品进行了负加权。（Seguimiento Universidad de Navarra/University of Navarra Follow-up [SUN] Project）.参与者：来自SUN Project的总共10094名最初健康的西班牙参与者参与了该研究。招募开始于1999年12月21日，并正在进行中。主要结果测量：参与者被归类为有事件抑郁症，如果他们是免费的抑郁症和抗抑郁药物在基线和报告的医生作出的诊断，临床抑郁症和/或抗抑郁药物的使用在follow-up.Results：经过中位随访4.4年，480例新的抑郁症被确定。对MDP依从性的4个较高连续类别（以最低依从性类别为参考）的抑郁症的多重校正风险比（95%置信区间）分别为0.74（0.57-0.98）、0.66（0.50-0.86）、0.49（0.36-0.67）和0.58（0.44-0.77）（趋势P
Context: Adherence to the Mediterranean dietary pattern (MDP) is thought to reduce inflammatory, vascular, and metabolic processes that may be involved in the risk of clinical depression.Objective: To assess the association between adherence to the MDP and the incidence of clinical depression.Design: Prospective study that uses a validated 136-item food frequency questionnaire to assess adherence to the MDP. The MDP score positively weighted the consumption of vegetables, fruit and nuts, cereal, legumes, and fish; the monounsaturated- to saturated-fatty-acids ratio; and moderate alcohol consumption, whereas meat or meat products and whole-fat dairy were negatively weighted.Setting: A dynamic cohort of university graduates (Seguimiento Universidad de Navarra/University of Navarra Follow-up [SUN] Project).Participants: A total of 10094 initially healthy Spanish participants from the SUN Project participated in the study. Recruitment began on December 21, 1999, and is ongoing.Main Outcome Measure: Participants were classified as having incident depression if they were free of depression and antidepressant medication at baseline and reported a physician-made diagnosis of clinical depression and/or antidepressant medication use during follow-up.Results: After a median follow-up of 4.4 years, 480 new cases of depression were identified. The multiple adjusted hazard ratios (95% confidence intervals) of depression for the 4 upper successive categories of adherence to the MDP(taking the category of lowest adherence as reference) were 0.74 (0.57-0.98), 0.66 (0.50-0.86), 0.49 (0.36-0.67), and 0.58 (0.44-0.77) (P for trend