Functional LGE Imaging: Cardiac Phase-Resolved Assessment of Focal Fibrosis.
Functional LGE Imaging: Cardiac Phase-Resolved Assessment of Focal Fibrosis.
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功能性 LGE 成像：局灶性纤维化的心脏相位分辨评估。
DOI：
10.1109/embc.2019.8857759
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Akcakaya,Mehmet
中科院分区：
文献类型：
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作者：
Weingartner,Sebastian;Demirel,OmerBurak;Shenoy,Chetan;Schad,LotharR;Schulz-Menger,Jeanette;Akcakaya,Mehmet
心脏磁共振成像（CMR）是诊断各种缺血性和非缺血性心肌病的核心工具。CMR方案通常包括使用心脏相位分辨CINE MRI评估功能特性和使用晚期钆增强（LGE）成像表征心肌活力。传统的LGE成像需要在特定的反转时间内进行反转恢复准备，以消除健康心肌，这限制了对单个心脏期的获取。反过来，这就需要对心脏功能和生存能力进行单独扫描。在这项工作中，我们开发了一种在单次屏气下进行功能性LGE成像的新方法，采用三步方法：1)获取每个心脏阶段的ecg触发的多重对比数据，2)生成半定量松弛图，3)基于半定量图合成LGE成像对比度。对4名健康受试者和20名患者在1.5T和3T时进行了功能性LGE方法的评估。完全抑制健康心肌，达到40-80ms的时间分辨率，在组织界面处没有明显的时间模糊。局灶性瘢痕患者的功能性LGE显示，在所有心脏期，疤痕区域都有强大的高增强，可以直观地评估疤痕运动。所提出的技术具有简化和加速常见心脏成像方案的潜力，同时能够改进功能和活力信息的数据融合，以改进CMR的评估。
Cardiac Magnetic Resonance Imaging (CMR) is a central tool for diagnosis of various ischemic and non-ischemic cardiomyopathies. CMR protocols commonly comprise assessment of functional properties using cardiac phase-resolved CINE MRI and characterization of myocardial viability using late gadolinium enhancement (LGE) imaging. Conventional LGE imaging requires inversion recovery preparation with a specific inversion time to null the healthy myocardium, which restricts the acquisition to a single cardiac phase. In turn, this necessitates separate scans for cardiac function and viability. In this work, we develop a new method for functional LGE imaging in a single breath-hold using a three-step approach: 1) ECG-triggered multi-contrast data is acquired for each cardiac phase, 2) semi-quantitative relaxation maps are generated, 3) LGE imaging contrast is synthesized based on the semi-quantitative maps. The proposed functional LGE method is evaluated in four healthy subject and 20 patients at 1.5T and 3T. Thorough suppression of the healthy myocardium, as well as 40-80ms temporal resolution are achieved, with no visually apparent temporal blurring at tissue interfaces. Functional LGE in patients with focal scar demonstrates robust hyperenhancement in the scar area throughout all cardiac phases, allowing for visual assessment of scar motility. The proposed technique bears the potential to simplify and speedup common cardiac imaging protocols, while enabling improved data fusion of functional and viability information for improved evaluation of CMR.