Intestinal mast cells and eosinophils in relation to Strongyloides rattiadult expulsion from the small and large intestines of rats
Intestinal mast cells and eosinophils in relation to Strongyloides rattiadult expulsion from the small and large intestines of rats
复制标题
肠道肥大细胞和嗜酸性粒细胞与大鼠小肠和大肠中成年类圆线虫排出的关系
DOI：
10.1017/s0031182012001837
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发表时间：
2012
期刊：
影响因子：
2.4
通讯作者：
Shintoku Y
中科院分区：
文献类型：
--
作者：
Thang ND;Yajima I;Ohnuma S;Ohgami N;Kumasaka MY;Ichihara G. Kato M.;Shintoku Y
粘液肥大细胞（MMC）在小鼠小肠排出棒状圆线虫成虫过程中起重要作用。本文报道了该菌的大肠寄生。MMC在自然宿主大肠中的分布未见报道。我们研究了MMC的动力学，以及嗜酸性粒细胞，在上，下小肠，盲肠和结肠的感染大鼠。肥大细胞增多症的两个不同阶段被揭示：一个在小肠上部由“普通”成年人的刺激触发，另一个在结肠中由“免疫抵抗”成年人刺激，这些成年人在感染后19天左右开始寄生在结肠中。在所有4个肠道部位，MMC峰在成虫数量达到最大值后5-7天观察到，MMC峰的高度似乎取决于寄生成虫的数量，表明蠕虫本身在MMC积累中起重要作用。
Mucosal mast cells (MMC) play a crucial role in the expulsion of Strongyloides ratti adults from the small intestine of mice. We reported the large intestinal parasitism of S. ratti in rats, and there has been no report on MMC in the large intestine of the natural host. We studied kinetics of MMC, together with eosinophils, in the upper and lower small intestines, caecum and colon of infected rats. Two distinct phases of mastocytosis were revealed: one in the upper small intestine triggered by stimulation of ‘ordinary’ adults, and the other in the colon stimulated by ‘immune-resistant’ adults that started parasitizing the colon around 19 days post-infection. In all 4 intestinal sites, the MMC peaks were observed 5–7 days after the number of adult worms became the maximum and the height of MMC peaks appeared to be dependent on the number of parasitic adults, suggesting an important role played by worms themselves in the MMC buildup.