The Population of SAP and TSAP Isomers in Cyclen-Based Lanthanide(III) Chelates Is Substantially Affected by Solvent
The Population of SAP and TSAP Isomers in Cyclen-Based Lanthanide(III) Chelates Is Substantially Affected by Solvent
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DOI：
10.1021/ic101489t
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发表时间：
2010-10-04
影响因子：
4.6
通讯作者：
Woods, Mark
中科院分区：
文献类型：
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作者：
Miller, Kyle J.;Saherwala, Ali A.;Woods, Mark
LnDOTA-四酰胺螯合物中的正方形反棱柱/扭曲正方形反棱柱比率是控制水交换动力学和最终螯合物作为PARACEST MRI造影剂的效用的关键参数。在LnDOTA-四酰胺与叔酰胺的螯合物中，发现这两种结构异构体之间的这种比率和相互转化率显著依赖于溶剂和可能的其他局部环境因素。
The square antiprism/twisted square antiprism ratio in LnDOTA-tetraamide chelates is a critical parameter in governing water-exchange kinetics and ultimately the utility of a chelate as a PARACEST MRI contrast agent. In LnDOTA-tetraamide chelates with tertiary amides, this ratio and the rate of interconversion between these two structural isomers are found to be dramatically dependent upon the solvent and possibly other local environmental factors.