Magnesium sulfate enhances exercise performance and manipulates dynamic changes in peripheral glucose utilization
Magnesium sulfate enhances exercise performance and manipulates dynamic changes in peripheral glucose utilization
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DOI：
10.1007/s00421-009-1235-y
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发表时间：
2010-01-01
影响因子：
3
通讯作者：
Cheng, Fu-Chou
中科院分区：
文献类型：
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作者：
Cheng, Shiu-Min;Yang, Lin-Lan;Cheng, Fu-Chou
补充镁对运动表现的影响仍然存在争议。本研究考察了硫酸镁对运动性能和血糖代谢的影响。为了提供一种无创的连续运动测量方法，我们开发了一种自动血液采样系统，该系统与微透析分析仪相结合，用于检测有意识和自由运动的沙鼠在强迫游泳时葡萄糖代谢的动态变化。沙鼠在运动前30分钟用生理盐水或硫酸镁（90 mg kg(-1), ip）进行预处理。与对照组相比，硫酸镁处理组的持续时间显著增加71% （p < 0.01）。另一组沙鼠进行血样分析。在每只沙鼠的颈静脉内植入导管，通过计算机辅助采血器采集血液样本。血浆葡萄糖、乳酸和镁的基础水平分别为6245 +/- A 662、1067 +/- A 309和590 +/- A 50 μ M，各组间无显著差异。对照组和硫酸镁组游泳时血浆葡萄糖、乳酸和镁水平分别上升至基础水平的134、204%、369、220%和155、422% （p < 0.05）。游泳过程中，硫酸镁预处理使葡萄糖和镁水平分别升高至基础水平的175和302% (p < 0.05)，而乳酸水平降低至基础水平的150% （p < 0.05）。此外，在强迫游泳和恢复期，镁水平升高至基础水平的152 ~ 422% （p < 0.05）。本研究表明，硫酸镁可以提高强迫游泳运动的持续时间。此外，在强迫游泳期间，镁会提高葡萄糖水平，降低乳酸水平。这些结果表明，镁补充剂的积极作用可能有助于提高运动员的运动表现。
The effect of magnesium supplementation on exercise performance remains controversial. In the present study, the effects of magnesium sulfate on exercise performance and blood glucose metabolism were examined. In order to provide a non-invasive measure of continuous exercise, we developed an auto-blood sampling system was coupled to a microdialysis analyzer to detect the dynamic changes in glucose metabolism in conscious and freely moving gerbils subjected to forced swimming. Gerbils were pretreated with saline or magnesium sulfate (90 mg kg(-1), ip) 30 min before exercise. The duration times were significantly increased by 71% in the magnesium sulfate-treated groups (p < 0.01) when compared with those in the control. Another group of gerbils were subjected to blood sampling assay. A catheter was implanted in the jugular vein of each gerbil for collecting blood samples by the computer-aided blood sampler. The basal levels of plasma glucose, lactate, and magnesium were 6,245 +/- A 662, 1,067 +/- A 309, and 590 +/- A 50 mu M, respectively, with no significant difference between groups. Plasma glucose, lactate, and magnesium levels increased to 134 and 204%, 369 and 220%, and 155 and 422% of basal levels during swimming in both the control and magnesium sulfate-treated groups, respectively (p < 0.05). Pretreatment with magnesium sulfate elevated glucose and magnesium levels to 175 and 302% of the basal levels (p < 0.05), respectively, whereas pretreatment with magnesium sulfate reduced the lactate levels 150% of the basal level (p < 0.05) during swimming. Furthermore, the magnesium levels increased to about 152-422% of basal levels during forced swimming and the recovery period (p < 0.05). The present study demonstrates that magnesium sulfate improved the duration time of forced swimming exercise. In addition, magnesium raised glucose levels and attenuated lactate levels during forced swimming. These results indicate that positive effects of magnesium supplementation may contribute to the enhancement of exercise performance in athletes.