Identification and gene organization of three novel members of the IL-1 family on human chromosome 2
Identification and gene organization of three novel members of the IL-1 family on human chromosome 2
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DOI：
10.1006/geno.2000.6184
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发表时间：
2000-06-01
期刊：
影响因子：
4.4
通讯作者：
Pan, Y
中科院分区：
文献类型：
--
作者：
Busfield, SJ;Comrack, CA;Pan, Y
白细胞介素 - 1（IL - 1）细胞因子家族成员在介导炎症反应中起重要作用。编码IL - 1α、IL - 1β和IL - 1受体拮抗剂（IL - 1Ra）的基因在人类2号染色体上聚集在450kb的范围内。通过搜索表达序列标签（EST）数据库并对2号染色体的这一区域进行测序，我们已经鉴定出三个与IL - 1家族具有同源性的新基因，我们将其命名为IL - 1相关蛋白1、2和3（IL - 1RP1、IL - 1RP2和IL - 1RP3）。这三个基因都包含一个IL - 1家族共有的特征性基序，并且似乎与IL - 1Ra的关系更为密切。与IL - 1Ra的细胞内形式相似，这些基因缺乏常规的疏水信号序列。这些基因的表达似乎高度局限于各种上皮细胞群。我们的研究结果表明，在先前定义的IL - 1基因簇内存在其他IL - 1基因家族成员，并指出2号染色体的这一区域是IL - 1基因复制的进化热点。这些基因可能在炎症反应中具有重要作用。（C）2000学术出版社
Members of the IL-1 family of cytokines are important in mediating inflammatory responses. The genes encoding IL-1 alpha, IL-beta, and the IL-1 receptor antagonist (IL-1Ra) are clustered within 450 kb on human chromosome 2q. By searching the EST databases and sequencing this region of chromosome 2, we have identified three novel genes that show homology to the IL-1 family, which we have named IL-1-related protein 1, 2, and 3 (IL-1RP1, IL-1RP2, and IL-1RP3). All three genes contain a signature motif common to the IL-1 family and appear to be more closely related to IL-1Ra. Similar to the intracellular form of IL-1Ra, these genes lack conventional hydrophobic signal sequences. The expression of these genes appears to be highly restricted to various epithelial cell populations. Our results demonstrate the existence of additional IL-1 gene family members within the previously defined IL-1 cluster and point to this region of chromosome 2 as an evolutionary hotspot for IL-1 gene duplication. These genes may prove to have an important role in inflammatory responses. (C) 2000 Academic Press.