Blood pressure lowering in patients with diabetes--one level might not fit all.
Blood pressure lowering in patients with diabetes--one level might not fit all.
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DOI：
10.1038/nrcardio.2010.182
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发表时间：
2011-01
影响因子：
49.6
通讯作者：
Pepine, Carl J.
中科院分区：
文献类型：
--
作者：
Cooper-DeHoff, Rhonda M.;Egelund, Eric F.;Pepine, Carl J.
高血压和糖尿病经常同时发生，导致同时患有这两种疾病的患者的并发症和死亡率增加。糖尿病患者的血压(BP)目标一直比非糖尿病患者更具侵略性。尽管降低BP的好处是有据可查的，但缺乏支持这一更激进目标的数据。事实上，降低BP可能并不总是更好。我们回顾了随机临床试验中关于高血压和糖尿病患者血压治疗的现有证据，以及可用的观察数据。我们还考虑了与J形曲线相关的证据，J形曲线反映了血压与糖尿病患者预后之间的关系，并根据患者的个体风险提出了治疗BP的建议，而不是基于全球指南推荐的激进BP目标。未来，个性化的方法将最大限度地发挥治疗的好处。
Hypertension and diabetes mellitus frequently occur together, leading to increased complications and mortality in patients with both these conditions. Blood pressure (BP) goals for patients with diabetes have consistently been more aggressive than for patients without diabetes. Although the benefits of lowering BP are well documented, data to support this more aggressive goal are lacking. In fact, lowering BP might not always be better. We review the available evidence regarding BP treatment in patients with hypertension and diabetes from randomized clinical trials, as well as available observational data. We also consider evidence related to the J-shaped curve, which reflects the relationship between BP and outcomes in patients with diabetes, and make recommendations for treatment of BP on the basis of a patient’s individual risk, as opposed to on the basis of aggressive BP targets recommended by global guidelines. In the future, a personalized approach will maximize the benefits from treatment.
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影响因子：
120.7
作者：
Cooper-DeHoff, Rhonda M.;Gong, Yan;Handberg, Eileen M.;Bavry, Anthony A.;Denardo, Scott J.;Bakris, George L.;Pepine, Carl J.
通讯作者：
Pepine, Carl J.
DOI：
10.1056/nejmoa1001288
发表时间：
2010-07-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
ACCORD Study Group;ACCORD Eye Study Group;Chew EY;Ambrosius WT;Davis MD;Danis RP;Gangaputra S;Greven CM;Hubbard L;Esser BA;Lovato JF;Perdue LH;Goff DC Jr;Cushman WC;Ginsberg HN;Elam MB;Genuth S;Gerstein HC;Schubart U;Fine LJ
通讯作者：
Fine LJ
影响因子：
8.3
作者：
Bakris, GL;Gaxiola, E;Pepine, CJ
通讯作者：
Pepine, CJ
影响因子：
2.8
作者：
Cushman, William C.;Grimm, Richard H., Jr.;Basile, Jan N.
通讯作者：
Basile, Jan N.
DOI：
10.1056/nejmoa1001282
发表时间：
2010-04-29
期刊：
The New England journal of medicine
影响因子：
--
作者：
ACCORD Study Group;Ginsberg HN;Elam MB;Lovato LC;Crouse JR 3rd;Leiter LA;Linz P;Friedewald WT;Buse JB;Gerstein HC;Probstfield J;Grimm RH;Ismail-Beigi F;Bigger JT;Goff DC Jr;Cushman WC;Simons-Morton DG;Byington RP
通讯作者：
Byington RP