SOCIAL HOUSING CONDITIONS INFLUENCE ESCAPE DEFICITS PRODUCED BY UNCONTROLLABLE STRESS - ASSESSMENT OF THE CONTRIBUTION OF NOREPINEPHRINE
SOCIAL HOUSING CONDITIONS INFLUENCE ESCAPE DEFICITS PRODUCED BY UNCONTROLLABLE STRESS - ASSESSMENT OF THE CONTRIBUTION OF NOREPINEPHRINE
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DOI：
10.1016/s0163-1047(81)90839-6
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
SKLAR, LS
中科院分区：
文献类型：
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作者：
ANISMAN, H;SKLAR, LS
一系列实验评估了无法控制的压力对逃避行为的影响，以及对被关在社会隔离或群体中的小鼠大脑多巴胺(DA)和去甲肾上腺素(NE)水平的影响。暴露在60次不可避免的脚电击下，明显扰乱了逃生行为。在单独饲养的小鼠中，缺陷的程度比集体饲养的小鼠更明显。在最初应激后168小时内出现的逐渐增加的逃逸缺陷似乎是由于休克治疗和隔离之间的相互作用。无论住房条件如何，暴露在60次不可避免的电击下都会导致下丘脑和海马体NE耗竭。暴露在30次电击下会导致隔离但不群居的小鼠去甲肾上腺素耗竭。虽然60次电击引起的NE耗竭是短暂的，但24小时后再次暴露于10次电击后再次引起NE耗竭。这种影响与居住条件无关，但隔离小鼠的去甲肾上腺素绝对值低于集体饲养的小鼠。从应激诱发的儿茶酚胺变化的贡献出发，讨论了失控应激所致的行为障碍。
A series of experiments assessed the effects of uncontrollable stress on escape behavior and on levels of brain dopamine (DA) and norepinephrine (NE) among mice housed in social isolation or in groups. Exposure to 60 inescapable foot-shocks markedly disrupted escape performance. The magnitude of the deficits was more pronounced among mice housed individually than in mice that had been group-housed. The progressively greater escape deficits seen over the 168-h period following the initial stress appeared to be due to the interaction between shock treatment and isolation. Exposure to 60 inescapable shocks resulted in hypothalamic and hippocampal NE depletion, regardless of housing condition. Exposure to 30 shocks resulted in NE depletion in isolated but not group-housed mice. Although the NE depletion produced by 60 shocks was transient, reexposure to 10 shocks 24 h later reinduced the depletion. Such an effect was independent of housing condition but absolute levels of NE were lower in isolated than group-housed mice. The behavioral deficits induced by uncontrollable stress were discussed in terms of the contribution of catecholamine changes induced by stress.