Treatment planning comparison of volumetric modulated arc therapy with Trilogy and Halcyon for bilateral breast cancer
Treatment planning comparison of volumetric modulated arc therapy with Trilogy and Halcyon for bilateral breast cancer
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Trilogy 和 Halcyon 容积调制弧疗法治疗双侧乳腺癌的治疗计划比较
DOI：
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Yong Yin
中科院分区：
文献类型：
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作者：
T. Sun;Xiu;Guifang Zhang;Qingtao Qiu;Chengqiang Li;Yong Yin
背景：Halcyon是瓦里安公司的一款新机器。本研究的目的是评估Halcyon在双侧乳腺癌体积调节弧线治疗中的剂量学。方法：对10例双侧乳腺癌患者的CT图像，生成4个设置场不同的Halcyon方案，采用Bonferroni多重比较检验对4个方案进行剂量学比较。设计了Trilogy和Halcyon上的整体和部分弧形计划，称为T-4arc， T-8arc， H-4arc和H-8arc。处方剂量为50gy，按2gy分次。所有方案均采用Eclipse 15.5版治疗计划系统设计。采用Mann-Whitney U试验比较了同一加速器中整体和部分弧面的剂量学差异。为了进一步比较Trilogy和Halcyon之间的计划质量和交付效率，选择了更好的Halcyon计划。结果：高质量超高电压锥束CT设置场的Halcyon方案与其他Halcyon方案相比，可提高计划靶体积（PTV）的Dmean、D2和V107以及心脏、左心室（LV）和肺部的V5和Dmean。与t -4弧方案相比，t -8弧方案心脏、肺和肝脏的平均剂量和低剂量体积均显著降低。心脏V5、V20、V30、V40、Dmean，左室V20、V30、V40、Dmean，左前降支V30、V40、Dmax、Dmean，肺V5、V40， H-8arc均显著高于H-4arc （p<0.05）。与Trilogy的方案相比，Halcyon的方案降低了心脏和左室的高剂量体积，但增加了心脏的平均剂量。两种加速剂对LAD的剂量及肺V20、V30均无显著性差异。与Trilogy相比，Halcyon的计划显著增加了皮肤剂量，但也显著缩短了递送时间。结论：在双侧乳腺癌放疗中，Halcyon的全弧线方案比部分弧线方案具有更大的剂量学优势。虽然心脏和皮肤剂量的平均剂量增加，但心脏亚结构和其他OARs的剂量与Trilogy相当，并且递送时间显着缩短。
Background: The Halcyon is a new machine from the Varian company. The purpose of this study was to evaluate the dosimetry of the Halcyon in treatment of bilateral breast cancer with volumetric modulated arc therapy. Methods: On CT images of 10 patients with bilateral breast cancer, four Halcyon plans with different setup fields were generated, and dosimetric comparisons using Bonferroni’s multiple comparisons test were conducted among the four plans. Whole and partial arc plans on the Trilogy and the Halcyon, referred to as T-4arc, T-8arc, H-4arc and H-8arc, were designed. The prescription dose was 50 Gy in 2-Gy fractions. All plans were designed with the Eclipse version 15.5 treatment planning system. The dosimetric differences between whole and partial arc plans in the same accelerator were compared using the Mann-Whitney U test. The better Halcyon plan was selected for the further dosimetric comparison of the plan quality and delivery efficiency between the Trilogy and the Halcyon. Results:Halcyon plans with high‐quality megavoltage cone beam CT setup fields increased the Dmean, D2 and V107 of the planning target volume (PTV) and the V5 and Dmean of the heart, left ventricle (LV) and lungs compared with other Halcyon setup plans. The mean dose and low dose volume of the heart, lungs and liver were significantly decreased in T-8arc plans compared to T-4arc plans. In terms of the V5, V20, V30, V40 and Dmean of the heart, the V20, V30, V40 and Dmean of the LV, the V30, V40, Dmax and Dmean of the left anterior descending artery (LAD), and the V5 and V40 of lungs, H-8arc was significantly higher than H-4arc (p<0.05). Compared with the Trilogy’s plans, the Halcyon’s plans reduced the high-dose volume of the heart and LV but increased the mean dose of the heart. For the dose of the LAD and the V20 and V30 of lungs, there was no significant difference between the two accelerators. Compared with the Trilogy, plans on the Halcyon significantly increased the skin dose but also significantly reduced the delivery time. Conclusion: For the Halcyon, the whole-arc plans have more dosimetric advantages than partial-arc plans in bilateral breast cancer radiotherapy. Although the mean dose of the heart and the skin dose are increased, the doses of the cardiac substructure and other OARs are comparable to the Trilogy, and the delivery time is significantly reduced.
DOI：
10.1016/s0360-3016(02)04617-5
发表时间：
2003-06-01
影响因子：
7
作者：
Wu, QW;Mohan, R;Schmidt-Ullrich, R
通讯作者：
Schmidt-Ullrich, R