NSAID therapy effects on healing of bone, tendon, and the enthesis.
NSAID therapy effects on healing of bone, tendon, and the enthesis.
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DOI：
10.1152/japplphysiol.00053.2013
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发表时间：
2013-09
影响因子：
3.3
通讯作者：
Bailey Su;J. O’Connor
中科院分区：
文献类型：
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作者：
Bailey Su;J. O’Connor
非甾体类抗炎药（NSAID）通常用于治疗骨骼损伤。非甾体抗炎药减轻疼痛和炎症的能力是众所周知的。然而，非甾体抗炎药治疗对骨骼损伤愈合的影响尚不明确。非甾体抗炎药抑制环氧合酶活性，减少前列腺素的合成，前列腺素是促炎性脂质信号分子。环氧合酶活性的抑制可以影响许多生理过程。 NSAID 治疗对骨骼、肌腱和肌腱与骨骼连接处（附着点）愈合的影响已在动物和细胞培养模型中进行了研究，但人体研究很少。使用具有不同药理学特性的不同非甾体抗炎药、给药方案的差异以及研究模型和结果测量的差异使得研究之间的比较变得复杂。在这篇综述中，我们总结了骨、肌腱和附着点愈合的机制，并描述了 NSAID 治疗对每个过程的影响。确定非甾体抗炎药治疗对骨骼组织愈合的影响将使临床医生能够适当地管理患者的病情并改善愈合结果。
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of skeletal injuries. The ability of NSAIDs to reduce pain and inflammation is well-established. However, the effects of NSAID therapy on healing of skeletal injuries is less defined. NSAIDs inhibit cyclooxygenase activity to reduce synthesis of prostaglandins, which are proinflammatory, lipid-signaling molecules. Inhibition of cyclooxygenase activity can impact many physiological processes. The effects of NSAID therapy on healing of bone, tendon, and the tendon-to-bone junction (enthesis) have been studied in animal and cell culture models, but human studies are few. Use of different NSAIDs with different pharmacological properties, differences in dosing regimens, and differences in study models and outcome measures have complicated comparisons between studies. In this review, we summarize the mechanisms by which bone, tendon, and enthesis healing occurs, and describe the effects of NSAID therapy on each of these processes. Determining the impact of NSAID therapy on healing of skeletal tissues will enable clinicians to appropriately manage the patient's condition and improve healing outcomes.