Original antigenic sin in ferrets: the response to sequential infections with influenza viruses.
Original antigenic sin in ferrets: the response to sequential infections with influenza viruses.
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DOI：
10.4049/jimmunol.97.2.177
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发表时间：
1966-08
影响因子：
4.4
通讯作者：
R. Webster
中科院分区：
文献类型：
--
作者：
R. Webster
雪貂感染流感病毒导致产生大量低亲和力的抗体分子。随着时间的推移，抗体分子的数量减少，而平均亲和力增加。雪貂连续感染血清学相关病毒会导致与第一种病毒反应的抗体分子数量显着增加。该抗体的亲合力与再感染前的抗体相似。与第二种病毒反应的抗体是二级质量的。相关病毒二次感染后 18 至 21 天的抗体群在亲和力方面存在异质性，一些抗体与一种或另一种感染病毒反应，一些抗体与两种病毒反应。
Infection of ferrets with influenza viruses resulted in the production of large numbers of antibody molecules of low avidity. With the passage of time the number of antibody molecules decreased while the average avidity increased. Sequential infection of ferrets with serologically related viruses caused a marked increase in the number of antibody molecules reacting with the first virus. The avidity of this antibody was similar to that of the antibody before reinfection. The antibody reacting with the second virus was of secondary quality. The antibody population 18 to 21 days after secondary infection with a related virus was heterogeneous in terms of avidity, some of the antibodies reacting with either one or the other of the infecting viruses and some reacting with both viruses.