Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer
Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer
复制标题
DOI：
10.1021/nl051679d
复制
发表时间：
2005-12-01
期刊：
影响因子：
10.8
通讯作者：
Kataoka, K
中科院分区：
文献类型：
--
作者：
Ideta, R;Tasaka, F;Kataoka, K
使用超分子纳米医疗装置（即由聚合物胶束制剂封装的新型树突状光敏剂（DP））对渗出性年龄相关性黄斑变性（AMD）的光动力疗法（PDT）进行了评估。 DP 特有的树枝状结构可防止其核心敏化剂聚集，从而引发高效的光化学反应。凭借其对脉络膜新生血管 (CNV) 病变的高度选择性积累，该治疗可实现非常有效的 CNV 闭塞，同时将不利的光毒性降至最低。
Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensitizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.