Neuropsychological deficits in human immunodeficiency virus type 1 clade C-seropositive adults from South India
Neuropsychological deficits in human immunodeficiency virus type 1 clade C-seropositive adults from South India
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DOI：
10.1080/13550280701258407
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发表时间：
2007-01-01
影响因子：
3.2
通讯作者：
Kumar, Mahendra
中科院分区：
文献类型：
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作者：
Das Gupta, Jayashree;Satishchandra, P.;Kumar, Mahendra
大多数关于人类免疫缺陷病毒1型（HIV-1）血清阳性（HIV-1+）受试者的认知功能的研究都是在美国和欧洲进行的，在这些地区，进化枝B感染占主导地位。然而，在世界其他地区，如印度南部，那里C型艾滋病毒最常见，HIV-1的流行率正在增加。标准化的神经心理学测试被用来评估119名感染C型HIV-1的成年人的认知功能，他们没有服用抗逆转录病毒药物。受试者没有神经或精神疾病，功能正常。神经心理学测试的表现进行了比较，性别，年龄和教育相匹配的规范性数据来自一个样本的540名健康志愿者和一个匹配的队列的126名健康，HIV-1血清阴性个体。在血清阳性受试者中，60.5%有轻度至中度的认知缺陷，其特征是流畅性、工作记忆和学习记忆领域的缺陷。所有受试者都没有严重的认知缺陷。根据由CD 4计数定义的免疫抑制水平，将HIV-1+样本分组（< 200、201-499和> 500个细胞/mm（3））和病毒载量（< 5000、5001- 30，000、30，001 - 99，999、100，000 - 1，000，000和> 1，000，001个拷贝）。尽管免疫抑制最严重的组（CD 4计数< 200个细胞/mm 3或病毒载量> 1，000，001拷贝）的人数较少，但与免疫功能较好的组相比，他们的视觉工作记忆受损率更高。轻度至中度的认知障碍可以在标准化神经心理学测试中确定，在没有任何临床可识别的功能障碍的C分支感染的HIV-1+成人中。认知缺陷的患病率与西方世界感染进化枝B病毒的抗逆转录病毒治疗初治个体中报道的相似。
Most studies of cognitive functioning in human immunodeficiency virus type 1 (HIV-1)-seropositive (HIV-1+) subjects have been done in the United States and Europe, where clade B infections predominate. However, in other parts of the world such as South India, where clade C HIV is most common, the prevalence of HIV-1 is increasing. Standardized neuropsychological tests were used to assess cognitive functioning in a sample of 119 adults infected with clade C HIV-1 who were not on antiretroviral medications. The subjects did not have neurological or psychiatric illness and were functioning adequately. Neuropsychological test performance was compared with gender-, age-, and education-matched normative data derived from a sample of 540 healthy volunteers and a matched cohort of 126 healthy, HIV-1-seronegative individuals. Among the seropositive subjects, 60.5% had mild to moderate cognitive deficits characterized by deficits in the domains of fluency, working memory, and learning and memory. None of the subjects had severe cognitive deficits. The HIV-1+ sample was classified into groups according to the level of immune suppression as defined by CD4 count (< 200, 201-499, and > 500 cells/mm(3)) and viral load (< 5000, 5001-30,000, 30,001-99,999, 100,000-1,000,000, and > 1,000,001 copies). Although the most immunosuppressed group (CD4 count < 200 cells/mm(3) or viral load > 1,000,001 copies) was small, their rate of impairment in visual working memory was greater when compared to groups with better immune functioning. Mild to moderate cognitive deficits can be identified on standardized neuropsychological tests in clade C-infected HIV-1+ adults who do not have any clinically identifiable functional impairment. The prevalence of cognitive deficits is similar to that reported in antiretroviral treatment-naive individuals infected with clade B virus in the western world.