Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp I.: Taxonomy, fermentation and biological activities
Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp I.: Taxonomy, fermentation and biological activities
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DOI：
10.7164/antibiotics.56.226
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发表时间：
2003-03-01
影响因子：
3.3
通讯作者：
Lam, KS
中科院分区：
文献类型：
--
作者：
Li, WY;Leet, JE;Lam, KS
在诺卡菌w -12651 （ATCC 202099）培养物中鉴定出噻唑肽抗生素诺卡那星I、II和III。它们在体外对多种革兰氏阳性细菌表现出强大的活性（ng/ml），包括多重耐药病原体，如耐甲氧西林金黄色葡萄球菌（MRSA）、多重耐药屎肠球菌（MREF）和完全耐青霉素肺炎链球菌（PRSP），并在全身金黄色葡萄球菌感染小鼠模型中表现出出色的体内疗效。
Thiazolyl peptide antibiotics, nocathiacin I, II and III, were identified in a culture of Nocardia sp. WW-12651 (ATCC 202099). They exhibit potent in vitro activity (ng/ml)against a wide spectrum of Gram-positive bacteria, including multiple-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), multi-drug resistant Enterococcus faecium (MREF) and fully penicillin-resistant Streptococcus pneumoniae (PRSP), and demonstrate excellent in vivo efficacy in a systemic Staphylococcus aureus infection mice model.