[Analysis of distant metastasis and related factors of head and neck mucosal melanoma].
[Analysis of distant metastasis and related factors of head and neck mucosal melanoma].
复制标题
头颈部黏膜黑色素瘤远处转移及相关因素分析
DOI：
10.13201/j.issn.1001-1781.2018.14.009
复制
发表时间：
2018
影响因子：
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通讯作者：
Z. G. Huang
中科院分区：
文献类型：
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作者：
W. Guo;G. Yin;X. Chen;Z. G. Huang
目的：分析头颈部黏膜恶性黑色素瘤远处转移的特点及相关因素，为更好的治疗和控制患者生存期提供帮助。方法：回顾性分析我院2004年1月至2016年12月收治的头颈部黏膜黑色素瘤患者，通过随访，对其中37例有远处转移的患者进行分析，包括远处转移的发生率、特异性转移及预后、时间等，控制患者的年龄和性别，在无远处转移的患者中按1∶1随机抽取37例。采用χ 2检验、Kaplan-Meier分析及多因素Logistic回归模型分析头颈部黏膜黑色素瘤远处转移的相关因素。结果：从住院到远处转移的时间为5-98个月，中位进展时间为18个月。37例中死亡27例，存活10例，其中肺转移占32.43%（12/37），腹膜转移占16.22%（6/37），骨转移占5.41%（2/37），存在多器官转移经χ 2检验和Kaplan_Meier分析，无论有无色素沉着，术后放疗、AJCC分期和手术方式均为显著性影响因素，多因素Logistic回归模型显示AJCC分期，并且色素沉积的存在与转移有关。结论：发现时多脏器转移，脑转移较少.根据AJCC分期，晚期患者通常预示着手术后预后不良和远处转移。无色素性黑色素瘤的患者病变远处转移的机会很大。。
Objective:To analyze the characteristics and related factors of distant metastasis of head and neck mucosal melanoma, so as to provide better help for the treatment and the control of patients' survival. Method:Retrospectively analyze the patients of head and neck mucosal melanoma who were treated in our hospital from January 2004 to December 2016, through follow-up, of which 37 cases of patients with metastatic disease were analyzed which including the incidence of distant metastasis, specific metastasis and prognosis, time, etc.The age and gender of the patients were controlled, and 37 cases of 1∶1 were selected randomly in the patients who had no distant metastasis. χ² test, Kaplan-Meier analysis and multiple factor logistics regression model were used to analyze the related factors of distant metastasis of head and neck mucosal melanoma. Result: The time from hospitalization to distant metastasis was 5-98 months, and the median progression time was 18 months. 27 people died in the 37 cases, 10 people were still alive,which lung metastasis accounted for 32.43%(12/37) , peritoneal metastasis accounted for 16.22% (6/37), bone metastases accounted for 5.41%(2/37), the presence of multiple organ metastasis (lung, liver, brain) patients accounted for 45.95%(17/37).χ² test and Kaplan_Meier analysis showed that no matter whether there was pigmentation or not, postoperative radiotherapy, AJCC staging and operation mode were the significant factors.Finally,multiple factor logistics regression model showed AJCC staging, and the presence of pigment deposition was associated with metastasis. Conclusion: There is a wide variety of multiple organ metastasis when found.Less brain metastases. According to the AJCC stage, patients with advanced stage usually predict poor prognosis and distant metastasis after operation.The patients' lesion without pigmented melanoma have a great chance of distant metastasis..
转移性肺癌小鼠模型肺血管化的显微 CT 分析。
DOI：
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发表时间：
2021
期刊：
影响因子：
--
作者：
Sukhbaatar A;Kuriu S;Mori S;Kodama T.
通讯作者：
Kodama T.