Relationship between preexisting mental disorders and prognosis of gynecologic cancers: A case-control study.
Relationship between preexisting mental disorders and prognosis of gynecologic cancers: A case-control study.
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先前存在的精神障碍与妇科癌症预后之间的关系：病例对照研究。
DOI：
10.1111/jog.14053
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Kikkawa F.
中科院分区：
文献类型：
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作者：
Tamauchi S;Kajiyama H;Moriyama Y;Yoshihara M;Ikeda Y;Yoshikawa N;Nishino K;Niimi K;Suzuki S;Kikkawa F.
癌症治疗涉及长期治疗和随访，精神障碍（MD）通常会影响治疗过程。因此，在这项研究中，我们回顾性分析病例涉及妇科癌症与MD和澄清精神病和癌症预后之间的关系MethodsPatients与妇科癌症和MD从2003年1月至2016年8月招募在这项研究中。病例仅限于那些在癌症前被诊断出MD的人。还分析了无MD的对照患者。病例和对照组均调整了年龄，癌症类型和癌症stage.ResultsA共54例妇科癌症和MD，以及108例对照无MD，包括在内。患者的中位年龄为52岁。关于癌症类型的详细信息如下：11例卵巢癌，26例子宫体癌和17例宫颈癌。其中精神分裂症25例，抑郁症15例，双相情感障碍4例，其他疾病10例。患者和对照组之间的5年生存率无显著差异。然而，在晚期宫颈癌中，由于初始治疗完成率较低，预后明显较差。此外，晚期宫颈癌患者的化疗完成率显着降低相比，与其他妇科恶性肿瘤。ConclusionMental disorders不影响妇科癌症的预后，除了晚期宫颈癌。因此，改善初始治疗完成率低似乎是改善晚期宫颈癌预后的一个焦点。
AimCancer treatment involves long‐term therapy and follow‐up, with mental disorders (MD) often affecting the treatment process. Hence, in this study, we retrospectively analyze cases involving gynecologic cancer with MD and clarify the relationship between psychosis and cancer prognosis.MethodsPatients with both gynecologic cancer and MD from January 2003 to August 2016 were recruited in this study. Cases were limited to those whose MD had been diagnosed before their cancer. Control patients without MD were also analyzed. Both cases and controls were adjusted for age, cancer type, and cancer stage.ResultsA total of 54 patients with gynecologic cancer and MD, as well as 108 controls without MD, were included. The median age of the patients was 52 years. Details regarding cancer type were as follows: 11 ovarian cancers, 26 uterine corpus cancers and 17 cervical cancers. Among these, 25 schizophrenia cases, 15 depressive disorders, 4 bipolar disorders and 10 other MD were recorded. No significant differences in the 5‐year survival rate were found between patients and controls. In advanced‐stage cervical cancer, however, the prognosis was significantly poor given the low rate of initial treatment completion. Moreover, patients with advanced‐stage cervical cancer had significantly lower chemotherapy completion rates compared to those with other gynecologic malignancies.ConclusionMental disorders do not affect the prognosis of gynecologic cancers, except for advanced cervical cancer. Accordingly, improving the low rate of initial treatment completion seems to be a focal point for better prognosis in advanced cervical cancer.