Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex.
Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex.
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DOI：
10.3389/fcell.2023.1153624
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发表时间：
2023
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
真核生物中基因表达程序的准确和精确调控涉及转录、mRNA稳定性和翻译的协调控制。近年来，关于3′端非翻译区序列元件在mRNA降解调控中的作用的研究取得了重大进展，并出现了一个模型，其中Ccr 4-Not复合物的募集是mRNA降解调控的关键步骤。Ccr 4-Not复合物向靶mRNA的募集导致由复合物的Caf 1和Ccr 4催化亚基介导的去腺苷化。去腺苷化后，5′帽结构被去除，mRNA发生5′-3′降解。本文综述了人类Ccr 4-Not复合物在mRNA胞质去腺苷化中的作用，特别关注其通过3 '非翻译区序列基序招募到mRNA的机制、密码子使用以及涉及poly的一般机制（A）尾巴。
Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation. In recent years, significant progress has been made about the role of sequence elements in the 3′ untranslated region for the regulation of mRNA degradation, and a model has emerged in which recruitment of the Ccr4-Not complex is the critical step in the regulation of mRNA decay. Recruitment of the Ccr4-Not complex to a target mRNA results in deadenylation mediated by the Caf1 and Ccr4 catalytic subunits of the complex. Following deadenylation, the 5′ cap structure is removed, and the mRNA subjected to 5′-3′ degradation. Here, the role of the human Ccr4-Not complex in cytoplasmic deadenylation of mRNA is reviewed, with a particular focus on mechanisms of its recruitment to mRNA by sequence motifs in the 3′ untranslated region, codon usage, as well as general mechanisms involving the poly(A) tail.
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影响因子：
3.7
作者：
Doidge R;Mittal S;Aslam A;Winkler GS
通讯作者：
Winkler GS
影响因子：
14.9
作者：
Chen Y;Khazina E;Izaurralde E;Weichenrieder O
通讯作者：
Weichenrieder O
影响因子：
4.8
作者：
Boenisch, Clemens;Temme, Claudia;Wahle, Elmar
通讯作者：
Wahle, Elmar
影响因子：
3.3
作者：
Aslam, Akhmed;Mittal, Saloni;Winkler, G. Sebastiaan
通讯作者：
Winkler, G. Sebastiaan
DOI：
10.1261/rna.045252.114
发表时间：
2014-09
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Chowdhury A;Kalurupalle S;Tharun S
通讯作者：
Tharun S