Current Directions in Stress and Human Immune Function.
Current Directions in Stress and Human Immune Function.
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DOI：
10.1016/j.copsyc.2015.03.007
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发表时间：
2015-10-01
影响因子：
5.9
通讯作者：
Segerstrom, Suzanne C
中科院分区：
文献类型：
--
作者：
Morey, Jennifer N;Boggero, Ian A;Scott, April B;Segerstrom, Suzanne C
根据经验，心理压力与人体免疫系统的失调有关，但这些影响在每种情况或人群中并不相同。最近的研究在理解免疫失调的风险因素以及这些风险发生的原因方面取得了长足的进步。本文综述了应激-免疫关系的机制和介质，环境在决定应激免疫反应是适应性还是非适应性中的作用，以及早期逆境暴露儿童、老年人和临床诊断个体的应激-免疫关系。本文综述的工作对进一步阐明心理应激对免疫的影响具有重要意义，并为该领域的研究提供了新的方向。
Psychological stress has been linked empirically with dysregulation of facets of the human immune system, yet these effects are not the same in every situation or population. Recent research has made strides towards understanding risk factors for immune dysregulation as well as why these risks occur. This review discusses mechanisms and mediators underlying the stress-immune relation, the role of context in determining whether an immunologic responses to stress is adaptive versus maladaptive, and the stress-immune relation in populations including children exposed to early adversity, older adults, and individuals with clinical diagnoses. The reviewed work holds great promise for further elucidating the circumstances under which psychological stress has immunological consequences, and provides new directions for work in this field.