Endurance training increases metabolic rate and norepinephrine appearance rate in older individuals.
Endurance training increases metabolic rate and norepinephrine appearance rate in older individuals.
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耐力训练可以提高老年人的代谢率和去甲肾上腺素出现率。
DOI：
10.1152/ajpendo.1991.261.2.e233
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
DanforthJr,E
中科院分区：
文献类型：
--
作者：
Poehlman,ET;DanforthJr,E
我们研究了19名老年人（64 +/- 1.6岁）8周耐力训练计划（骑自行车运动）对静息代谢率（RMR）和去甲肾上腺素（NE）动力学的影响。训练前后，RMR，NE动力学，最大耗氧量（VO 2 max），身体成分，仰卧位血压，估计能量摄入量，空腹血糖，胰岛素和甲状腺激素水平进行了测量。训练后RMR增加了10%。由于NE出现率增加21%，NE清除率无变化，训练后NE静息浓度增加24%。训练增加了最大摄氧量（14%; P <0.01）和能量摄入（12%; P <0.01），而身体成分没有变化。训练后仰卧位血压和血糖较低，而空腹血浆胰岛素水平无变化。RMR的增加与NE出现率较高（r = 0.57; P = 0.05）和能量摄入增加（r = 0.56; P = 0.05）相关。这两个因素共同解释了RMR变化的49%（r2）。血压的变化与NE动力学的变化无关。我们的结论是，耐力训练增加了总能量消耗在老年人的身体活动的直接能量成本和提高RMR。这种增加部分由健康老年人NE出现率增加和食物摄入量增加介导。
We examined the effects of an 8-wk endurance training program (cycling exercise) on resting metabolic rate (RMR) and norepinephrine (NE) kinetics in 19 older persons (64 +/- 1.6 yr). Before and after training, RMR, NE kinetics, maximal O2 consumption (VO2max), body composition, supine blood pressure, estimated energy intake, and fasting levels of glucose, insulin, and thyroid hormones were measured. RMR increased 10% after training. Resting concentrations of NE increased 24% after training due to a 21% increase in NE appearance rate and no change in NE clearance. Training increased VO2max (14%; P less than 0.01) and energy intake (12%; P less than 0.01), whereas no change was noted in body composition. Supine blood pressure and plasma glucose were lower after training, whereas no change was noted in fasting levels of plasma insulin. The increase in RMR was associated with a higher rate of NE appearance (r = 0.57; P = 0.05) and with increase in energy intake (r = 0.56; P = 0.05). Together these two factors accounted for 49% (r2) of the variation of the change in RMR. Changes in blood pressure were not associated with changes in NE kinetics. We conclude that endurance training increases total energy expenditure in older individuals by the direct energy cost of physical activity and by elevating RMR. This increase is partially mediated by an increased NE appearance rate and increased food intake in healthy older individuals.