You Can't Always Get What You Want: The Influence of Choice on Nocebo and Placebo Responding
You Can't Always Get What You Want: The Influence of Choice on Nocebo and Placebo Responding
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DOI：
10.1007/s12160-016-9772-1
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发表时间：
2016-06-01
影响因子：
3.8
通讯作者：
Petrie, Keith J.
中科院分区：
文献类型：
--
作者：
Bartley, Hannah;Faasse, Kate;Petrie, Keith J.
选择可能对药物治疗的有效性和副作用有重要影响。我们调查了有选择药物与没有选择药物对反安慰剂和安慰剂反应的影响。61名参与者被随机分配，要么选择，要么被分配到两种等效的-受体阻滞剂药物（实际上是安慰剂）中的一种来治疗检查前焦虑。无选择组的反安慰剂反应更强，选择组的安慰剂反应更强。无选择组的参与者认为药片的副作用明显多于选择组（p = 0.045），特别是在24小时的随访中（p = 0.002）。选择组在心率方面表现出比非选择组更强的安慰剂反应。没有选择的药物增加了反安慰剂效应，减少了安慰剂对治疗的反应。
Choice may be an important influence on the effectiveness and side effects of medical treatments.We investigated the impact of having a choice of medication compared to no choice on both nocebo and placebo responding.Sixty-one participants were randomly assigned to either choose between or be assigned to one of the two equivalent beta-blocker medications (actually placebos) for pre-examination anxiety.There was a greater nocebo response in the no choice group and an increased placebo response in the choice group. Participants in the no choice group attributed significantly more side effects to the tablet than the choice group (p = 0.045), particularly at the 24-h follow-up (p = 0.002). The choice group showed a stronger placebo response in heart rate than the non-choice group.Not being given a choice of medication increased the nocebo effect and reduced the placebo response to the treatment.