The molecular actions of thyroid hormone in bone
The molecular actions of thyroid hormone in bone
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DOI：
10.1016/s1043-2760(03)00144-9
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发表时间：
2003-10
影响因子：
10.9
通讯作者：
J. H. Duncan Bassett;G. Williams
中科院分区：
文献类型：
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作者：
J. H. Duncan Bassett;G. Williams
甲状腺激素（T3）是软骨内骨和膜内骨正常发育所必需的，在骨量的线性生长和维持中起重要作用。儿童期T3缺乏导致骨骼发育迟缓和生长停滞，而T3过量导致生长加速和骨形成。在成人甲状腺毒症中，骨重建增加，其特征在于骨吸收和骨形成之间的不平衡，这导致净骨丢失和骨质疏松后骨折的风险增加。这些临床观察表明T3在骨骼发育和代谢中的重要性。然而，T3在骨中作用的分子机制知之甚少。在这里，我们提供了软骨细胞，成骨细胞和破骨细胞的T3调节，以及甲状腺激素受体（TR）亚型在骨骼发育中的作用的概述。T3和TRs在核受体串扰、前受体配体代谢、硫酸乙酰肝素蛋白多糖合成和血管生成中的可能作用也被考虑。
Thyroid hormone (T3) is essential for the normal development of endochondral and intramembranous bone and plays an important role in the linear growth and maintenance of bone mass. Childhood T3deficiency results in retardation of skeletal development and growth arrest, whereas T3excess leads to accelerated growth and bone formation. In adult thyrotoxicosis, there is increased bone remodelling, characterized by an imbalance between bone resorption and formation, which results in net bone loss and an increased risk for posteoporotic fracture. These clinical observations demonstrate the importance of T3in skeletal development and metabolism. Nevertheless, the molecular mechanisms of T3action in bone are poorly understood. Here, we provide an overview of T3regulation of chondrocytes, osteoblasts and osteoclasts, and the actions of thyroid hormone receptor (TR) isoforms in skeletal development. The possible roles of T3and TRs in nuclear receptor crosstalk, prereceptor ligand metabolism, heparan sulfate proteoglycan synthesis and angiogenesis are also considered.