TRANSPOSITION OF STRUCTURAL GENES TO AN EXPRESSION SEQUENCE ON A LINEAR PLASMID CAUSES ANTIGENIC VARIATION IN THE BACTERIUM BORRELIA-HERMSII
TRANSPOSITION OF STRUCTURAL GENES TO AN EXPRESSION SEQUENCE ON A LINEAR PLASMID CAUSES ANTIGENIC VARIATION IN THE BACTERIUM BORRELIA-HERMSII
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DOI：
10.1038/318257a0
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发表时间：
1985-01-01
期刊：
影响因子：
64.8
通讯作者：
BARBOUR, AG
中科院分区：
文献类型：
--
作者：
PLASTERK, RHA;SIMON, MI;BARBOUR, AG
在赫氏疏螺旋体（一种引起回归热的螺旋体）中，两种常见的可变主要蛋白（VMP）类型（7和21）表达之间的转换与DNA重排有关。细胞类型7和21都含有线性质粒上的未转录的7和21 VMP基因。血清型7细胞含有与另一线性质粒上的表达序列融合的7 VMP基因的额外拷贝。转换为21血清型涉及去除转录的7VMP基因并将21 VMP基因的拷贝融合到该相同的表达序列。因此，线性质粒之间的重组可以激活不同的VMP基因。
In Borrelia hermsii, a spirochaete that causes relapsing fever, the switch between expression of two frequent variable major protein (VMP) types (7 and 21) is associated with a DNA rearrangement. Both cell types 7 and 21 contain untranscribed 7 and 21 VMP genes on linear plasmids. The serotype 7 cells contain an additional copy of the 7 VMP gene fused to an expression sequence on another linear plasmid. Switching to the 21 serotype involves removal of the transcribed 7 VMP gene and fusion of a copy of the 21 VMP gene to this same expression sequence. Thus, recombination between linear plasmids can activate different VMP genes.