Origins and fates of cardiovascular progenitor cells
Origins and fates of cardiovascular progenitor cells
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DOI：
10.1016/j.cell.2008.02.002
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发表时间：
2008-02-22
期刊：
影响因子：
64.5
通讯作者：
Mummery, Christine
中科院分区：
文献类型：
--
作者：
Wu, Sean M.;Chien, Kenneth R.;Mummery, Christine
多能心脏祖细胞存在于包括人类在内的许多哺乳动物的胎儿和成年心脏中，并在胚胎干细胞分化过程中作为中间体形成。尽管有相似的生物学特性，但这些不同的心脏前体细胞群体的分子特性似乎是不同的。阐明这些细胞群体的起源和谱系关系将加速药物筛选和细胞治疗等临床应用，并有助于揭示心脏疾病的发病机制。
Multipotent cardiac progenitor cells are found in the fetal and adult heart of many mammalian species including humans and form as intermediates during the differentiation of embryonic stem cells. Despite similar biological properties, the molecular identities of these different cardiac progenitor cell populations appear to be distinct. Elucidating the origins and lineage relationships of these cell populations will accelerate clinical applications such as drug screening and cell therapy as well as shedding light on the pathogenic mechanisms underlying cardiac diseases.