DAMGO and DPDPE facilitation of brain stimulation reward thresholds is blocked by the dopamine antagonist cis-flupenthixol
DAMGO and DPDPE facilitation of brain stimulation reward thresholds is blocked by the dopamine antagonist cis-flupenthixol
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DOI：
10.1016/s0028-3908(97)00075-0
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发表时间：
1997-08-01
影响因子：
4.7
通讯作者：
Kornetsky, C
中科院分区：
文献类型：
--
作者：
Duvauchelle, CL;Fleming, SM;Kornetsky, C
研究了多巴胺神经传递在阿片类奖赏中的作用，采用非速率测量方法确定脑刺激奖赏(BSR)阈值。伏隔内注Mu和Delta特异性多肽D-Ala(2)、N-Me-Phe(4)、Gly-ol(5)-Enkephalin和D-Pen(2)、D-Pen(5)-Enkephalin可显著降低BSR阈值。多巴胺D1/D2拮抗剂顺式氟苯硫醇在单独给药时不会显著改变阈值，但可以阻断这些效应。这些数据表明，BSR的µ阿片增强和增量阿片增强都是多巴胺依赖的。(C)1997年爱思唯尔科学有限公司。
The role of dopamine neurotransmission in opioid reward was investigated using a rate-independent measure for determining brain stimulation reward (BSR) thresholds. Intra-accumbens infusions of the mu- and delta-specific peptides, D-Ala(2), N-Me-Phe(4), Gly-ol(5)-Enkephalin and D-Pen(2), D-Pen(5)-Enkephalin caused significant lowering of BSR thresholds. The dopamine D1/D2 antagonist, cis-flupenthixol, blocked these effects at a dose that did not significantly alter thresholds when given alone. These data suggest both mu- and delta-opioid potentiation of BSR is dopamine dependent. (C) 1997 Elsevier Science Ltd.