Roles of the pre-SMA and rIFG in conditional stopping revealed by transcranial magnetic stimulation
Roles of the pre-SMA and rIFG in conditional stopping revealed by transcranial magnetic stimulation
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DOI：
10.1016/j.bbr.2015.08.024
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发表时间：
2016-01-01
影响因子：
2.7
通讯作者：
Juan, Chi-Hung
中科院分区：
文献类型：
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作者：
Lee, Hon Wah;Lu, Ming-Shan;Juan, Chi-Hung
尽管补充前运动区(Pre-SMA)和右下额下回(RIFG)都被证明对反应抑制起关键作用，但对于它们在这一过程中的作用仍存在相当大的分歧。在本研究中，我们通过应用离线theta-Burst经颅磁刺激，研究了条件停止信号任务中SMA前和rIFG的因果关系。这项任务引入了持续条件，它需要与围棋试验中相同的运动反应，但会像停止试验中那样吸引注意力。我们发现，在继续试验中，减速量存在很大的个体差异。暂时抑制SMA前活性延长了对继续试验反应轻微的受试者的持续反应时，而中断rIFG不会导致显著的性能变化，无论减慢的程度如何。我们的结果有助于理解SMA前的作用，因为它提供了因果证据，表明它参与了条件停止期间继续试验的反应减慢，并且很可能它在更新运动规划和重新启动抑制反应方面的效率与减慢的量有关。(C)2015爱思唯尔B.V.保留所有权利。
Although both the presupplementary motor area (pre-SMA) and the right inferior frontal gyrus (rIFG) have been demonstrated to be critical for response inhibition, there is still considerable disagreement over the roles they play in the process. In the present study, we investigated the causal relations of the pre-SMA and the rIFG in a conditional stop-signal task by applying offline theta-burst transcranial magnetic stimulation. The task introduced a continue condition, which requires the same motor response as in a go trial but captures attention as in a stop trial. We found great individual differences in the amount of slowing on continue trials. Temporary suppression of pre-SMA activity prolonged the continue RT in participants who slowed little in response to continue trials, whereas disruption of the rIFG did not lead to significant changes in performance irrespective of the degree of slowing. Our results contribute to the understanding of the role of the pre-SMA by providing causal evidence that it is involved in response slowing on continue trials during conditional stopping, and it is likely that its efficiency in updating motor planning and reinitiating an inhibited response was associated with the amount of slowing. (C) 2015 Elsevier B.V. All rights reserved.