Is the ferret a suitable species for studying perinatal brain injury?
Is the ferret a suitable species for studying perinatal brain injury?
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DOI：
10.1016/j.ijdevneu.2015.06.005
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发表时间：
2015-10-01
影响因子：
1.8
通讯作者：
Juul, Sandra E.
中科院分区：
文献类型：
--
作者：
Empie, Kristen;Rangarajan, Vijayeta;Juul, Sandra E.
早产并发症通常会破坏正常的大脑发育和/或对发育中的大脑造成直接损害，导致神经发育结果不佳。围产期脑损伤的生理相关动物模型可以增进我们对这些影响的理解，从而为开发治疗方法和改善长期结果提供机会。虽然目前可用的小动物模型有优点，但也存在显着的缺点，限制了研究结果向人类的转化。大型动物模型，如新生猪、羊和非人类灵长类动物，具有与人类更相似的复杂大脑发育，但这些动物价格昂贵，而且绵羊和仔猪的发育测试有限。雪貂（Mustela putorittsfuro）生来是无脑的，出生后经过皮质折叠形成复杂的环脑。这篇综述探讨了雪貂是否可以提供一种新的新生儿脑部疾病中间动物模型，该模型具有小动物回旋晚熟大脑的优点。它总结了雪貂大脑生长和发育的属性，使其成为模拟围产期脑损伤的有吸引力的动物。我们假设，由于雪貂的先天特征，它们在新生儿神经发育研究中具有巨大潜力。 (C) 2015 Elsevier Ltd. 保留所有权利。
Complications of prematurity often disrupt normal brain development and/or cause direct damage to the developing brain, resulting in poor neurodevelopmental outcomes. Physiologically relevant animal models of perinatal brain injury can advance our understanding of these influences and thereby provide opportunities to develop therapies and improve long-term outcomes. While there are advantages to currently available small animal models, there are also significant drawbacks that have limited translation of research findings to humans. Large animal models such as newborn pig, sheep and nonhuman primates have complex brain development more similar to humans, but these animals are expensive, and developmental testing of sheep and piglets is limited. Ferrets (Mustela putoritts furo) are born lissencephalic and undergo postnatal cortical folding to form complex gyrencephalic brains. This review examines whether ferrets might provide a novel intermediate animal model of neonatal brain disease that has the benefit of a gyrified, altricial brain in a small animal. It summarizes attributes of ferret brain growth and development that make it an appealing animal in which to model perinatal brain injury. We postulate that because of their innate characteristics, ferrets have great potential in neonatal neurodevelopmental studies. (C) 2015 Elsevier Ltd. All rights reserved.