Bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species
Bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species
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DOI：
10.1056/nejmoa065987
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发表时间：
2007-06-07
影响因子：
158.5
通讯作者：
Koehler, Jane E.
中科院分区：
文献类型：
--
作者：
Eremeeva, Marina E.;Gerns, Helen L.;Koehler, Jane E.
巴尔通体属在全球范围内引起严重的人类感染，包括杆菌性血管瘤病、奥罗亚热、战壕热和心内膜炎。我们描述了一个病人谁有发烧和脾肿大后，前往秘鲁，也有菌血症的有机体，类似巴尔通体杆菌，病原体的奥罗亚热，这是地方性的秘鲁。然而，遗传分析显示，这种难养细菌代表了一种以前未培养和未命名的巴尔通体属，与B密切相关。clarridgeiae，与B亲缘关系较远。杆状的。我们的特点是这种分离，包括它的能力，引起发热和持续的菌血症恒河猴。与这种新描述的病原体相关的感染途径和人类疾病负担目前尚不清楚。
Bartonella species cause serious human infections globally, including bacillary angiomatosis, Oroya fever, trench fever, and endocarditis. We describe a patient who had fever and splenomegaly after traveling to Peru and also had bacteremia from an organism that resembled Bartonella bacilliformis, the causative agent of Oroya fever, which is endemic to Peru. However, genetic analyses revealed that this fastidious bacterium represented a previously uncultured and unnamed bartonella species, closely related to B. clarridgeiae and more distantly related to B. bacilliformis. We characterized this isolate, including its ability to cause fever and sustained bacteremia in a rhesus macaque. The route of infection and burden of human disease associated with this newly described pathogen are currently unknown.