Alterations of GABA(B) binding caused by acute and chronic lead administration
Alterations of GABA(B) binding caused by acute and chronic lead administration
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DOI：
10.55782/ane-1996-1124
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发表时间：
1996-01-01
影响因子：
1.4
通讯作者：
Waskiewicz, J
中科院分区：
文献类型：
--
作者：
Waskiewicz, J
The effect of lead on GABA(B) binding was studied on membranes obtained from acute and chronically lead-treated rats. Acute lead treatment reduced both GABA(B) affinity (K-D) by about 30% and density of receptor (B-max) by about 15%. On the contrary chronic lead treatment increased receptor capacity by about 20% in spite of decreased receptor affinity by 25%. Both acute and chronic lead treatment shiffted displacement curves toward higher concentration of non-labelled compound(decreased affinity). The results show that lead can affect the GABA(B) binding in two ways: by reducing affinity of binding and by altering capacity of binding.
