RESPONSE OF C-FIBER NOCICEPTORS IN THE ANESTHETIZED MONKEY TO HEAT STIMULI - CORRELATION WITH PAIN THRESHOLD IN HUMANS
RESPONSE OF C-FIBER NOCICEPTORS IN THE ANESTHETIZED MONKEY TO HEAT STIMULI - CORRELATION WITH PAIN THRESHOLD IN HUMANS
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DOI：
10.1113/jphysiol.1995.sp020767
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发表时间：
1995-06-15
影响因子：
5.5
通讯作者：
CAMPBELL, JN
中科院分区：
文献类型：
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作者：
TILLMAN, DB;TREEDE, RD;CAMPBELL, JN
1. 采用梯度热刺激比较了温度变化率对猴子伤害感受器反应的影响和对人类热痛阈值的影响。记录麻醉猴子毛状皮肤的25个皮肤C纤维机械热痛觉感受器（CMHs）。采用汇聚楼梯技术确定8名受试者掌侧前臂的热痛阈值。热痛阈值随着刺激斜坡率的增加而降低。相比之下，CMH热阈值（定义为第一个动作电位发生时的表面温度）随着刺激斜坡率的增加而增加。因此，决定热痛阈值的热刺激的特性与控制伤害感受器反应启动的热刺激的特性是不同的。热斜坡过程中CMHs的峰值放电频率随刺激斜坡速率的增加而增加。热痛阈值与伤害感受器的最小放电率（0.5 Hz）相关，而与动作电位启动阈值无关。
1. Ramped heat stimuli were used to compare the effects of rate of temperature change on the responses of monkey nociceptors and on heat pain threshold in human subjects. Recordings were made from twenty-five cutaneous C fibre mechano-heat nociceptors (CMHs) innervating the hairy skin in the anaesthetized monkey. Heat pain thresholds were determined on the volar forearm of eight human subjects using a converging staircase technique.2. The heat pain threshold decreased as stimulus ramp rate increased. In contrast, the CMH heat threshold, defined as the surface temperature at which the first action potential occurred, increased as stimulus ramp rate increased. Thus, the properties of the heat stimulus that dictate heat pain threshold are different from the properties of the heat stimulus that govern the initiation of a response in nociceptors.3. Peak discharge frequency of CMHs during the heat ramp increased with stimulus ramp rate. Heat pain threshold was correlated with achievement of a minimum discharge rate in nociceptors (0.5 Hz), rather than with the threshold for action potential initiation.