Report of a fatal case of dengue infection with hepatitis:: Demonstration of dengue antigens in hepatocytes and liver apoptosis
Report of a fatal case of dengue infection with hepatitis:: Demonstration of dengue antigens in hepatocytes and liver apoptosis
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DOI：
10.1016/s0046-8177(99)90230-7
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发表时间：
1999-09-01
期刊：
影响因子：
3.3
通讯作者：
Deubel, V
中科院分区：
文献类型：
--
作者：
Couvelard, A;Marianneau, P;Deubel, V
本文报告一例登革热感染并发脾破裂和肝炎的死亡病例。显微镜研究显示，脾破裂伴血肿的多个区域，并在尸检时获得的肝脏样本中发现坏死灶。虽然在几例登革出血热病例中报告了肝炎，但对肝损伤的机制仍知之甚少。在这种情况下，免疫组织化学显示，DEN病毒抗原主要是在周围的坏死灶肝细胞检测。通过原位检测DNA断裂，发现凋亡的肝细胞与DEN病毒感染的肝细胞共存。这些结果表明，肝细胞是DEN病毒在肝脏中复制的主要场所，DEN病毒在体内诱导肝细胞凋亡。《人文哲学》30：1106-1110。版权所有（C）1999 W.B.桑德斯公司
A fatal case of dengue (DEN) infection associated with a spleen rupture and with hepatitis is reported here. Microscopic studies showed numerous areas of spleen rupture with hematomas and revealed necrotic foci in liver samples obtained at autopsy. Although hepatitis was reported in several cases of DEN fever, the mechanism of liver injury remains poorly understood. In this case, immunohistochemistry showed that DEN viral antigens were mostly detected in hepatocytes surrounding the necrotic foci. By in situ detection of DNA fragmentation, apoptotic hepatocytes were found to be colocated with DEN virus-infected hepatocytes. These findings suggest that hepatocytes are the major sites of DEN virus replication in the liver and that DEN virus induces apoptosis of hepatocytes in vivo. HUM PATHOL 30:1106-1110. Copyright (C) 1999 by W.B. Saunders Company.