TRANSIENT HYPO-THYROIDISM ASSOCIATED WITH PREMATURITY, SEPSIS, AND RESPIRATORY-DISTRESS
TRANSIENT HYPO-THYROIDISM ASSOCIATED WITH PREMATURITY, SEPSIS, AND RESPIRATORY-DISTRESS
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DOI：
10.1007/bf00447374
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发表时间：
1979-01-01
影响因子：
3.6
通讯作者：
DINKEL, E
中科院分区：
文献类型：
--
作者：
SCHONBERGER, W;GRIMM, W;DINKEL, E
本文对60例新生儿重症监护病房新生儿在3个月内进行了促甲状腺激素（TSH）和甲状腺素（T_4）的连续测定。7例患者（12%）表现为短暂的甲状腺功能减退症的基础上低T4和高TSH值。其中只有一名患有胎粪吸入和肺炎的患者没有呼吸窘迫综合征。这些患者中有4例患有败血症。所有患者均在孕37周前出生，出生体重均低于2200 g。两名患者的胎龄和出生体重组进行性下降的T4极甲状腺功能减退值没有同时升高的TSH。死亡的5例患者中有2例进行了甲状腺组织学研究。这些发现胶体耗尽囊泡，上皮脱落和甲状腺血管化突出。短暂性甲状腺功能减退症的早期识别和治疗可能挽救生命。
Serial thyrotropin [TSH] and thyroxine [T4] determinations were performed in 60 neonates admitted to a hospital for neonatal intensive care within 3 mo. Seven patients (12%) showed transient hypothyroidism on the basis of low T4 and high TSH values. Only one of these patients, who had meconium aspiration and pneumonia, did not have the respiratory distress syndrome. Four of these patients had sepsis. All of the patients were born before 37 gestational weeks and had birth weights under 2200 g. Two patients of this gestational age and birth weight group had a progressive fall of T4 to extremely hypothyroid values without simultaneous elevation of TSH. Two of the 5 patients who died had histological studies of their thyroids. These revealed colloid-depleted vesicles, desquamated epithelium and prominent vascularization of the thyroid. Early recognition and therapy of transient hypothyroidism may be life saving.