Roles and Sources of Calcium in Synaptic Exocytosis.
Roles and Sources of Calcium in Synaptic Exocytosis.
复制标题
钙在突触胞吐作用中的作用和来源。
DOI：
10.1007/978-3-031-34229-5_6
复制
发表时间：
2023
影响因子：
--
通讯作者：
Niu,Longgang
中科院分区：
文献类型：
--
作者：
Wang,Zhao-Wen;Riaz,Sadaf;Niu,Longgang
钙离子 (Ca2+) 在触发神经递质释放中发挥着关键作用。释放速率与突触前Ca2+浓度直接相关，呈超线性关系。触发突触小泡融合的 Ca2+ 有两个主要来源：通过质膜中的电压门控 Ca2+ 通道流入，并通过兰尼碱受体从内质网释放。本章将介绍突触前神经末梢 Ca2+ 的来源、神经递质释放速率与 Ca2+ 浓度之间的关系，以及在突触前部位达到触发突触胞吐作用所需的 Ca2+ 浓度的机制。
Calcium ions (Ca2+) play a critical role in triggering neurotransmitter release. The rate of release is directly related to the concentration of Ca2+at the presynaptic site, with a supralinear relationship. There are two main sources of Ca2+that trigger synaptic vesicle fusion: influx through voltage-gated Ca2+channels in the plasma membrane and release from the endoplasmic reticulum via ryanodine receptors. This chapter will cover the sources of Ca2+at the presynaptic nerve terminal, the relationship between neurotransmitter release rate and Ca2+concentration, and the mechanisms that achieve the necessary Ca2+concentrations for triggering synaptic exocytosis at the presynaptic site.