Aerobic exercise and lipids and lipoproteins in men: a meta-analysis of randomized controlled trials.
Aerobic exercise and lipids and lipoproteins in men: a meta-analysis of randomized controlled trials.
复制标题
DOI：
10.1016/j.jmhg.2005.09.003
复制
发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Kelley, Kristi S
中科院分区：
文献类型：
--
作者：
Kelley, George A;Kelley, Kristi S
背景技术背景：有氧运动被推荐用于改善脂蛋白和脂质水平，脂蛋白和脂质水平低于其最佳水平是心血管疾病的危险因素。缺乏证据表明运动可以有效降低这些水平，可能是由于研究规模较小。我们对研究进行了荟萃分析，以检查有氧运动对成年男性脂质和脂蛋白的影响。 方法：通过计算机文献检索、检索文章的交叉引用、手动检索和我们参考文献列表的专家评审检索研究。入选标准为随机对照试验，有氧运动≥8周，成年男性≥18岁，以期刊、论文或硕士论文形式发表的研究，1955年1月1日至2003年1月1日期间以英语发表的研究，以及对以下一种或多种脂质和脂蛋白的评估：总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDLC）和甘油三酯（TG）。所有编码均由两位作者进行，彼此独立。通过协商一致解决了差异。 研究结果：49项随机对照试验代表了来自2,990名男性（1,741名运动，1,249名对照）的67项结局，汇总进行分析。使用随机效应模型，观察到TC、HDL-C和TG的统计学显著性改善，并观察到LDL-C的下降趋势。变化相当于TC和HDL-C改善2%，LDL-C改善3%，TG改善9%。 结论：有氧运动可降低18岁及以上男性的TC和TG，升高HDL-C。
BACKGROUND: Aerobic exercise is recommended for improving lipoprotein and lipid levels which at less than their optimal levels are risk factors for cardiovascular disease. Evidence seems lacking for the effectiveness of exercise in reducing these levels, possibly due to small sizes in studies. We concluded a meta-analysis of the studies to examine the effects of aerobic exercise on lipids and lipoproteins in adult men. METHODS: Studies were retrieved via computerized literature searches, cross-referencing from retrieved articles, hand-searching, and expert review of our reference list. Inclusion criteria were randomized controlled trials, aerobic exercise ≥8 weeks, adult men ≥18 years of age, studies published in journal, dissertation, or master's thesis format, studies published in the English-language between January 1, 1955 and January 1, 2003, and assessment of one or more of the following lipids and lipoproteins: total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDLC), and triglycerides (TG). All coding was conducted by both authors, independent of each other. Discrepancies were resolved by consensus. RESULTS: Forty-nine randomized controlled trials representing up to 67 outcomes from 2,990 men (1,741 exercise, 1,249 control) were pooled for analysis. Using random-effects modeling, statistically significant improvements were observed for TC, HDL-C and TG, and a trend for decreases was observed for LDL-C. Changes were equivalent to improvements of 2% for TC and HDL-C, 3% of LDL-C, and 9% for TG. CONCLUSIONS: Aerobic exercise reduces TC and TG and increases HDL-C in men 18 years of age and older.