Expression of MSP58 in human colorectal cancer and its correlation with prognosis.
Expression of MSP58 in human colorectal cancer and its correlation with prognosis.
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MSP58在人结直肠癌中的表达及其与预后的相关性
DOI：
10.1007/s12032-012-0284-y
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Chen CS
中科院分区：
文献类型：
--
作者：
Shi H;Li SJ;Zhang B;Liu HL;Chen CS
我们已经报道了MSP 58通过细胞周期蛋白D1-细胞周期蛋白依赖性激酶4-p21途径调节结直肠癌细胞的增殖、发育和凋亡。本研究应用免疫组织化学方法检测了499例大肠癌组织中MSP 58蛋白的表达。分析各种临床病理特征与患者总体生存率之间的关系。采用Kaplan-Meier和考克斯回归分析MSP 58表达与499例结直肠癌患者生存率的关系。利用ROC曲线提供MSP 58评分预测结直肠癌患者局部复发和生存的敏感性和特异性。MSP 58的表达与浸润深度（P< 0.001）、局部复发（P= 0.008）、肿瘤分级（P = 0.002）、UICC分期（P< 0.001）呈正相关。Kaplan-Meier生存分析显示，5年随访期间，低表达MSP 58的结直肠癌患者的生存时间长于高表达MSP 58的结直肠癌患者（P< 0.001）。考克斯回归分析显示，MSP 58高表达（P< 0.001）、浸润深度> pT 1（P= 0.008）、远处转移（P< 0.001）、区域淋巴结转移（P <0.001）、局部复发（P= 0.007）是影响结直肠癌预后的独立因素。ROC曲线显示MSP 58表达水平评分确实为预测CRC患者局部复发和生存提供了最大的敏感性和特异性。我们的研究结果表明，MSP 58可能作为一种新的预后标志物，是独立的，并添加到，UICC分期系统。
We had reported that MSP58 regulates colorectal cancer cell proliferation, development, and apoptosis, by the cyclin D1-cyclin-dependent kinase 4-p21 pathway. In this study, MSP58 protein expression was examined by immunohistochemistry in 499 specimens of CRC. The relationship between various clinicopathological features and overall patient survival rate was analyzed. The association of MSP58 expression with the 499 CRC patients’ survival rate was assessed by Kaplan–Meier and Cox regression. Using ROC curve to provide sensitivity and specificity of the score of MSP58 predicts local recurrence and survival of CRC patients. The expression of MSP58 was positively correlated with the depth of invasion (P< 0.001), local recurrence (P= 0.008), tumor grade (P= 0.002), and UICC stage (P< 0.001). The Kaplan–Meier survival analysis demonstrated that the survival time of CRC patients with low expression of MSP58 was longer than those with high expression during the 5-year follow-up period (P< 0.001). COX regression analysis indicated that high expression of MSP58 (P< 0.001), depth of invasion >pT1(P= 0.008), distant organ metastasis (pM1) (P< 0.001), regional lymph node metastasis (≥pN1) (P< 0.001), and local recurrence (Yes) (P= 0.007) were independent, poor prognostic factors of CRC. ROC curve showed the score of MSP58 expression level did provide a maximal sensitivity and specificity to predict local recurrence and survival of CRC patients. Our results demonstrated MSP58 might serve as a novel prognostic marker that is independent of, and additive to, the UICC staging system.
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DOI：
10.1093/jnci/djp280
发表时间：
2009-10-07
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Siena S;Sartore-Bianchi A;Di Nicolantonio F;Balfour J;Bardelli A
通讯作者：
Bardelli A
RNAi 介导的 MSP58 抑制可降低人神经胶质瘤细胞系中的肿瘤生长、迁移和侵袭
影响因子：
5.3
作者：
Lin W;Zhang J;Zhang J;Liu X;Fei Z;Li X;Davidovic L;Tang Z;Shen L;Deng Y;Yang A;Han H;Zhang X;Yao L
通讯作者：
Yao L
影响因子：
3.6
作者：
Du, Xiulian;Wang, Qiang;Greene, Mark I.
通讯作者：
Greene, Mark I.
DOI：
10.1046/j.1432-1327.1998.2530734.x
发表时间：
1998-05-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Ren, Y;Busch, RK;Busch, H
通讯作者：
Busch, H
影响因子：
4.8
作者：
Lin, DY;Shih, HM
通讯作者：
Shih, HM