HIV-INFECTION, CIGARETTE-SMOKING AND CD4 + LYMPHOCYTE-T COUNTS - PRELIMINARY-RESULTS FROM THE SAN-FRANCISCO MENS HEALTH STUDY
HIV-INFECTION, CIGARETTE-SMOKING AND CD4 + LYMPHOCYTE-T COUNTS - PRELIMINARY-RESULTS FROM THE SAN-FRANCISCO MENS HEALTH STUDY
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DOI：
10.1097/00002030-199004000-00007
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发表时间：
1990-04-01
期刊：
影响因子：
3.8
通讯作者：
WINKELSTEIN, W
中科院分区：
文献类型：
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作者：
ROYCE, RA;WINKELSTEIN, W
在旧金山男性健康研究队列中，研究了吸烟对CD4+T淋巴细胞的影响。该队列是在1984年通过概率抽样建立的，目的是研究艾滋病毒感染。在所有男性中，吸烟与CD_4+细胞计数增加有关，但在艾滋病毒血清阳性男子中这种影响减弱(与吸烟者相比，非吸烟者与吸烟者相比，艾滋病毒血清阳性男子的中位数相差85个细胞/[亩]L)，而在艾滋病毒血清阴性的男子中，这种影响减弱(中位数相差230个细胞/L)。在未感染的男性中观察到的每天吸烟的香烟与CD+细胞计数之间的阳性剂量反应在感染的男性中显著降低(斜率87比27细胞/[亩]L)。对HIV血清转换者数据的分析表明，吸烟者在感染后的计数下降速度比不吸烟者更快，而且感染后不久对吸烟的反应变得不那么明显。这份报告表明，那些出于临床和/或研究目的监测艾滋病毒感染者体内CD4+细胞计数的人也应该考虑吸烟状况。
The effect of cigarette smoking on CD4+ T lymphocytes was investigated in the San Francisco Men's Health Study cohort. The cohort was established by probability sampling in 1984 to study infection with HIV. Smoking showed an association with increased CD4+ cell counts in all men but the effect was attenuated in HIV-seropositive men (85 cells/[mu] l difference in median counts, non-smokers compared with smokers) compared with HIV-seronegative men (230 cells/[mu] l difference in median counts). The positive dose response between packs smoked per day and CD4+ counts observed in uninfected men was substantially reduced in infected men (slope 87 versus 27 cells/[mu] l). Analysis of data from HIV seroconverters suggest that smokers' counts fall faster than non-smokers' following infection, and that response to smoking becomes less pronounced soon after infection. This report demonstrates that those who monitor CD4+ cell counts in HIV-infected individuals for clinical and/or research purposes should also consider smoking status.