Genomic privacy and limits of individual detection in a pool
Genomic privacy and limits of individual detection in a pool
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DOI：
10.1038/ng.436
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发表时间：
2009-09-01
期刊：
影响因子：
30.8
通讯作者：
Halperin, Eran
中科院分区：
文献类型：
--
作者：
Sankararaman, Sriram;Obozinski, Guillaume;Halperin, Eran
最近的研究表明，统计方法可用于根据全基因组关联研究 (GWAS) 报告的汇总数据来检测研究组中是否存在单个个体。我们对此类方法的统计功效进行了分析和实证研究。因此，我们的目标是为希望在不损害受试者隐私的情况下公开提供有限数量的 SNP 的研究人员提供定量指南。
Recent studies have demonstrated that statistical methods can be used to detect the presence of a single individual within a study group based on summary data reported from genomewide association studies (GWAS). We present an analytical and empirical study of the statistical power of such methods. We thereby aim to provide quantitative guidelines for researchers wishing to make a limited number of SNPs available publicly without compromising subjects' privacy.