Oral Transmucosal Abuse of Transdermal Fentanyl
Oral Transmucosal Abuse of Transdermal Fentanyl
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透皮芬太尼的口腔经粘膜滥用
DOI：
10.1177/0269881104042634
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发表时间：
2004
影响因子：
4.1
通讯作者：
A. Rabavilas
中科院分区：
文献类型：
--
作者：
I. Liappas;N. Dimopoulos;E. Mellos;O. Gitsa;A. Liappas;A. Rabavilas
透皮芬太尼是一种对慢性疼痛有效的阿片类镇痛药，由于易于给药，相对稳定的血清浓度和较长的剂量间隔等因素，芬太尼似乎是有利的。然而，在处方芬太尼贴片的患者中存在滥用和依赖的危险。我们提出了一个经皮芬太尼滥用的情况下，药物的给药途径被改变。我们的患者没有药物滥用史，患有慢性非恶性疼痛，使用芬太尼透皮贴片作为口服经黏膜药物，剂量增加了10倍。这种药物的滥用仅用于止痛目的，而不寻求焦虑和/或欣快感。经治疗和逐步减少芬太尼后，患者状况良好，目前正在经皮服用初始剂量的药物，未出现任何戒断症状。
Transdermal fentanyl is an opioid analgesic that is effective on chronic pain, and which appears to be advantageous due to several factors such as ease of administration, the relatively stable serum concentration and long dose intervals. Nevertheless, the danger of abuse and dependence exists among patients who are prescribed fentanyl patches. We present a case of transdermal fentanyl abuse, where the administration route of the drug was changed. Our patient, who had no history of substance abuse and who suffered from chronic nonmalignant pain, used the fentanyl transdermal patches as oral transmucosal medication, raising the dose by ten-fold. This abuse of the drug was only for analgesic purposes without seeking anxiolysis and/or euphoria. After treatment and progressive reduction of fentanyl, the patient remains in good condition, and is currently taking the initial dose of the drug transdermally, without having experienced any withdrawal symptoms.