CdSe/CdS/SiO2 core/shell/shell nanoparticles.
CdSe/CdS/SiO2 core/shell/shell nanoparticles.
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DOI：
10.1166/jnn.2007.438
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发表时间：
2007-07
影响因子：
--
通讯作者：
Mingqiang Zhu;Jason J. Han;Alexander D. Q. Li
中科院分区：
文献类型：
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作者：
Mingqiang Zhu;Jason J. Han;Alexander D. Q. Li
为了提高量子点在生物缓冲液中的稳定性和荧光成像中的生物相容性，在CdSe-ZnS核壳结构的量子点(QD)上涂覆了二氧化硅微球。我们发现，在硅壳生长过程之前，将量子点从有机相转移到水相是至关重要的。结果高产率地制备了高质量的CdSe-ZnS-SiO_2核-壳-壳纳米粒子，并用透射电子显微镜和动态光散射对其大小和分布进行了表征，得到了尺寸均匀、多分散性窄的纳米粒子。二氧化硅保护的量子点的单粒子荧光光谱表明，它们是比裸露的CdSe-ZnS纳米晶更强的发射体，具有一致的荧光强度和开关行为。
Quantum dots (QD) of a CdSe-ZnS core-shell structure are coated with silica spheres to improve their stability in biological buffers and biocompatibility in fluorescence imaging. We found that it was critical to transfer quantum dots from organic phase to aqueous phase before the silica shell growth process. As a result, high quality CdSe-ZnS-SiO2 core-shell-shell nanoparticles were prepared in high yields and their size and distribution are characterized with transmission electron microscopy and dynamic light scattering, which yielded uniform sizes and narrow polydispersity. Single particle fluorescence spectroscopy on the silica-protected quantum dots showed they were stronger emitters with consistent fluorescence intensity and "on-off" behaviors than bare CdSe-ZnS nanocrystals.