Brain activation evoked by perception of gaze shifts: the influence of context
Brain activation evoked by perception of gaze shifts: the influence of context
复制标题
DOI：
10.1016/s0028-3932(02)00146-x
复制
发表时间：
2003-01-01
期刊：
影响因子：
2.6
通讯作者：
McCarthy, G
中科院分区：
文献类型：
--
作者：
Pelphrey, KA;Singerman, JD;McCarthy, G
我们实验室以前的研究[神经科学杂志18(1998)2188；认知神经心理学17(2000)221]已经证明，当受试者看到眼睛转移视线的面孔时，上颞沟(STS)的离散区域被激活。在这里，我们调查了STS和其他大脑区域的活动在多大程度上受到感知到的凝视转移的影响，也就是说，当凝视转移正确或错误地获得了视觉目标时。15名受试者参与了一项与事件相关的功能磁共振成像实验，在实验中，他们观看了一张在每次跑步过程中保持存在的动画脸。在每次运行的21次试验中，一个小棋盘出现在角色视野内六个位置中的一个位置上，并闪烁。在“正确”测试中，角色的视线在延迟1到3个S后转向棋盘。在“错误”测试中，角色在同样的延迟后将目光转向空白处。在“无移位”测试中，角色的眼睛一动不动。与主要为右半球STS的无注视移位相比，凝视移位引起的血流动力学反应(HDR)明显更大。与S的1次移位相比，3次S的凝视诱发的高密度脑干反应峰值明显延迟。对于1个S移位，我们观察到了较强的语境效应，即错误引起了持续时间较长的动态再记录。虽然这项研究侧重于STS，但在顶内沟和梭形回也观察到了类似的影响。爱思唯尔科学有限公司出版。
Prior studies from our laboratory [Journal of Neuroscience 18 (1998) 2188; Cognitive Neuropsychology 17 (2000) 221] have demonstrated that discrete regions of the superior temporal sulcus (STS) are activated when a subject views a face in which the eyes shift their gaze. Here we investigated the degree to which activity in the STS and other brain regions is modulated by the context of the perceived gaze shift; that is, when the shift correctly or incorrectly acquires a visual target. Fifteen subjects participated in an event-related functional magnetic resonance imaging experiment in which they viewed an animated face that remained present throughout each run. On each of 21 trials within each run, a small checkerboard appeared and flickered at one of six locations within the character's visual field. On "correct" trials, the character shifted its gaze towards the checkerboard after a delay of 1 or 3 s. On "incorrect" trials, the character shifted its gaze towards empty space after the same delays. On "no shift" trials, the character's eyes did not move. Significantly larger hemodynamic responses (HDR) were evoked by gaze shifts compared to no gaze shifts in primarily right hemisphere STS. The gaze-evoked HDR was significantly delayed in peak amplitude for 3 s compared to 1 s shifts. For 1 s shifts, a strong effect of context was observed in which errors evoked a HDR with extended duration. Although this study focused upon STS, similar effects were also observed in the intraparietal sulcus and fusiform gyrus. Published by Elsevier Science Ltd.