Experimental study on changes in metabolic mechanism of papillary thyroid carcinoma complicated with Hashimoto's thyroiditis.
Experimental study on changes in metabolic mechanism of papillary thyroid carcinoma complicated with Hashimoto's thyroiditis.
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DOI：
10.1016/j.heliyon.2023.e20661
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发表时间：
2023-10
期刊：
影响因子：
4
通讯作者：
Meng, Zhaowei
中科院分区：
文献类型：
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作者：
Sun, Danyang;Zhang, Yujie;Wang, Dan;Zhao, Xue;Han, Rui;Li, Ning;Li, Xue;Li, Tingwei;Wang, Peng;Jia, Qiang;Tan, Jian;Zheng, Wei;Song, Lili;Meng, Zhaowei
关键词：
Whether the mechanism of thyroid papillary carcinoma (PTC) is the same in patients with a Hashimoto's thyroiditis (HT) background as compared with patients with a normal background remains a highly debated and controversial issue. In this study, we aimed to analyze the differences and similarities of the metabolic mechanism of PTC in normal and HT background, and to explore the relationship between HT and PTC. The ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometry (UPLC-Q-TOF/MS) technology was used to analyze 61 PTC patient tissues (31 HT background and 30 normal tissue (NC) background). Potential biomarkers were screened from principal component analysis (PCA) to orthogonal partial least square (OPLS) discriminant analysis. HMDB was searched to identify potential differential metabolites and final metabolic pathway analysis was performed by MetaboAnalyst 5.0. We analyzed the differential metabolites diagnostic accuracy through receiver operating characteristic (ROC) curves analysis. Seven different metabolites were screened from HT group and NC group, including arginine, glutamic acid, cysteine, citric acid, malic acid, uracil and taurine. Logistic regression model combined with ROC analysis of these 7 biomarkers had good discriminability for PTC (area under operating characteristic curve of HT group and NC group were 0.867 and 0.973, respectively). The HT group had specific metabolic pathways, including aminoacyl-tRNA biosynthesis, glycine, serine and threonine metabolism. The metabolic profiles of the NC and HT groups had important similarities and differences in PTC. The correlation of PTC with HT may be related to aminoacyl-tRNA biosynthesis, serine and threonine metabolism.
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影响因子：
5.6
作者：
Li R;Macnamara LM;Leuchter JD;Alexander RW;Cho SS
通讯作者：
Cho SS
影响因子：
1
作者：
Danis, N.;Comlekci, A.;Canda, T.
通讯作者：
Canda, T.
DOI：
10.4149/bll_2022_141
发表时间：
2022-01-01
影响因子：
1.5
作者：
Grigerova, Marianna;Kasko, Martin;Podoba, Jan
通讯作者：
Podoba, Jan
影响因子：
4.6
作者：
Kim, Su Jin;Lee, Seung-Eun;Il Kim, Young;Nam-Goong, Il Sung;Jung, Hyo Won;Kim, Eun Sook
通讯作者：
Kim, Eun Sook
影响因子：
4.6
作者：
通讯作者：
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