Malignant transformation of the mouse anorectal epithelium induced by an inoculated human cancer cell line
Malignant transformation of the mouse anorectal epithelium induced by an inoculated human cancer cell line
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DOI：
10.1007/s10620-004-9592-1
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发表时间：
2004-11-01
影响因子：
3.1
通讯作者：
Toh, Y
中科院分区：
文献类型：
--
作者：
Kuwano, H;Miyazaki, T;Toh, Y
将4种人类癌细胞系和1种小鼠癌细胞系接种于雌性裸鼠肛门直肠上皮下区。在这些细胞系中，两种细胞系（KATO III和Lu 135）显示出对相邻小鼠肛肠上皮非典型变化的潜在强制作用。此外，从3只接种KATO iii的小鼠身上获得的标本显示，小鼠上皮的恶性转化细胞在粘膜下浸润。这一令人兴奋和新奇的现象清楚地表明需要改变目前癌症组织单细胞起源的一般概念。这一有价值的新发现可能会改变肿瘤研究的基础，同时也为从分子生物学、细胞生物学和病理学等多个方面研究肿瘤发生机制的项目提供新的思路。此外，新的实验设计本身也非常有用，作为研究肿瘤发生机制的简单模型。
Four kinds of human cancer cell lines and one mouse caner cell line were inoculated into the subepithelial area of the anorectum of female nude mice. Among the cell lines, two cell lines (KATO III and Lu 135) showed the potential enforcement of atypical changes in the adjacent mouse anorectal epithelium. Moreover, the submucosal invasion of the malignant transformed cells of the mouse epithelium was demonstrated in specimens obtained from three KATO III-inoculated mice. This exciting and novel phenomenon clearly demonstrates the need to change the present general concept of a single-cell origin of cancer tissue. This valuable and novel discovery may change the basis of oncology research while also providing new ideas for projects to investigate the mechanisms of carcinogenesis from several aspects such as molecular biology, cell biology, and pathology. Moreover, the novel experimental design itself is also extremely useful as a simple model for investigating the mechanisms of oncogenesis.