Identification and Characterization of Adverse Drug Events in Primary Care
Identification and Characterization of Adverse Drug Events in Primary Care
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初级保健中药物不良事件的识别和表征
DOI：
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发表时间：
2017
影响因子：
1.4
通讯作者：
M. Nahata
中科院分区：
文献类型：
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作者：
K. Trinkley;H. Weed;Stuart J. Beatty;K. Porter;M. Nahata
本研究的目的是使用电子健康记录（EHR）识别和描述初级保健环境中的药物不良事件（ADE）。这项前瞻性、观察性研究招募了在门诊内科诊所就诊的任何药物变化的患者。通过EHR审查和电话访谈评估患者的ADE。由医生和药剂师使用分级工具独立评估ADE的因果关系、严重程度、可预防性和可改善性。701名完成研究的个体发生了1368次独特的药物变化（每人1.95次变化）。在226起疑似ADE中，68起（58%）在因果关系评估后被认为是“明确的”或“很可能的”; 21%是可预防的，40%是可改善的。仅2例ADE为严重或危及生命。与既往报告相比，初级保健中ADE的发生频率和严重程度有所下降，但可预防和可改善的ADE的发生率有所增加。
The purpose of this study was to identify and characterize adverse drug events (ADEs) in a primary care setting using an electronic health record (EHR). This prospective, observational study enrolled patients with any medication change who were seen at an outpatient internal medicine clinic. Patients were evaluated for ADEs by EHR review and telephone interview. ADEs were independently assessed for causality, severity, preventability, and ameliorability by a physician and a pharmacist using a grading instrument. There were 1368 unique medication changes for 701 individuals who completed the study (1.95 changes per person). Of the 226 suspected ADEs, 68 (58%) were deemed to be “definite” or “probable” following causality assessment; 21% were preventable and 40% ameliorable. Only 2 ADEs were serious or life-threatening. Compared with prior reports, ADEs in primary care have decreased in frequency and severity, yet the occurrence of preventable and ameliorable ADEs has increased.
通过计算机监测预防药物不良事件。
DOI：
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发表时间：
1992
期刊：
Proceedings. Symposium on Computer Applications in Medical Care
影响因子：
--
作者：
Evans,RS;Pestotnik,SL;Classen,DC;Bass,SB;Burke,JP
通讯作者：
Burke,JP