EFFECT OF PUBERTY ON RATES OF BONE-GROWTH AND MINERALIZATION - WITH OBSERVATIONS IN MALE DELAYED PUBERTY
EFFECT OF PUBERTY ON RATES OF BONE-GROWTH AND MINERALIZATION - WITH OBSERVATIONS IN MALE DELAYED PUBERTY
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DOI：
10.1136/adc.54.12.950
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发表时间：
1979-01-01
影响因子：
5.2
通讯作者：
TRANSBOL, I
中科院分区：
文献类型：
--
作者：
KRABBE, S;CHRISTIANSEN, C;TRANSBOL, I
本文测定了301例7-20岁正常儿童青少年和8例14-17岁体质性青春期延迟男童的骨矿含量和身高。在最后一组以及正常儿童和青少年亚群中测量血清睾酮[T]。男孩的生长突增与血清T的急剧增加相吻合，表明男女骨骼生长和矿化发生了巨大变化。在生长突增之后，线性生长显著减慢，而骨矿化急剧上升。当维持低水平的血清T时，如在青春期延迟时，这些骨骼生长和矿化的联合变化并没有发生。性腺激素可能是短暂生长突增以及骨矿化延长加速的真正启动剂。
The bone mineral content and body height were measured in 301 normal children and adolescents aged 7-20 yr and in 8 boys with constitutional delayed puberty aged 14-17 yr. Serum testosterone [T] was measured in the last group as well as in a subpopulation of the normal children and adolescents. The growth spurt, which coincided with a steep increase of serum T in boys, indicated a great change in skeletal growth and mineralization in both sexes. After the growth spurt, linear growth slowed down considerably while bone mineralization rose steeply. When low levels of serum T were maintained, as in delayed puberty, these combined changes of skeletal growth and mineralization did not occur. Gonadal hormones may be the true initiators of the short-lived growth spurt as well as of prolonged acceleration of bone mineralization.