Functional anatomy of intrinsic alertness:: evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere
Functional anatomy of intrinsic alertness:: evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere
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DOI：
10.1016/s0028-3932(98)00141-9
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发表时间：
1999-06-01
期刊：
影响因子：
2.6
通讯作者：
Willmes, K
中科院分区：
文献类型：
--
作者：
Sturm, W;de Simone, A;Willmes, K
Alertness, the most basic intensity aspect of attention, probably is a prerequisite for the more complex and capacity demanding domains of attention selectivity.从行为上来说，内在的警觉性代表了对觉醒和觉醒的内部（认知）控制；评估内在警觉性最佳水平的典型任务是在没有预先警告刺激的情况下测量简单的反应时间。到目前为止，在动物、病变和功能成像研究中仅揭示了促进警觉性的大脑网络的部分内容。 Here, in a O-15-butanol PET activation study in 15 right-handed young healthy male volunteers for this basic attention function we found an extended right hemisphere network including frontal (anterior cingulate-dorsolateral cortical)-inferior parietal-thalamic (pulvinar and possibly the reticular nucleus) and brainstem (ponto-mesencephalic tegmentum, possibly involving the locus coeruleus) structures, when subjects waited for并通过用右手拇指按下响应键来快速响应中心出现的白点。 (C) 1999 Elsevier Science Ltd. 保留所有权利。
Alertness, the most basic intensity aspect of attention, probably is a prerequisite for the more complex and capacity demanding domains of attention selectivity. Behaviorally, intrinsic alertness represents the internal (cognitive) control of wakefulness and arousal; typical tasks to assess optimal levels of intrinsic alertness are simple reaction time measurements without preceding warning stimuli. Up until now only parts of the cerebral network subserving alertness have been revealed in animal, lesion, and functional imaging studies. Here, in a O-15-butanol PET activation study in 15 right-handed young healthy male volunteers for this basic attention function we found an extended right hemisphere network including frontal (anterior cingulate-dorsolateral cortical)-inferior parietal-thalamic (pulvinar and possibly the reticular nucleus) and brainstem (ponto-mesencephalic tegmentum, possibly involving the locus coeruleus) structures, when subjects waited for and rapidly responded to a centrally presented white dot by pressing a response key with the right-hand thumb. (C) 1999 Elsevier Science Ltd. All rights reserved.